Evidence map›Paper›PMID 33466893›Full record

ArticleInternational journal of environmental research and public health2021

International Price Comparisons of Anticancer Drugs: A Scheme for Improving Patient Accessibility.

Jae Ho Jung, Dae Jung Kim, Kangho Suh, Jaeeun You, Je Ho Lee, Kyung In Joung, Dong Churl Suh

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jae Ho JungCollege of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
Dae Jung KimCollege of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
Kangho SuhDepartment of Pharmacy & Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15217, USA.ORCID 0000-0002-7906-9398
Jaeeun YouCollege of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
Je Ho LeeCollege of Pharmacy, Chung-Ang University, Seoul 06974, Korea.
Kyung In JoungGraduate School of Public Health, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-2974-9248
Dong Churl SuhCollege of Pharmacy, Chung-Ang University, Seoul 06974, Korea.ORCID 0000-0002-2304-8037
Chung-Ang University · KRNovartis (South Korea) · KRSeoul National University · KRUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe demand for implementing a new listing scheme to expedite patient access to novel oncology drugs has increased in South Korea. This study was conducted to compare the prices of anticancer drugs between eight countries and to explore the feasibility of a 'pre-listing and post-evaluation' scheme to expedite patient access to oncology drugs.

methodsThis study included 34 anticancer drugs, which were reimbursed between 1 January 2007 and 31 December 2017. The unit price and sales volume of the study drugs were collected from eight countries and IQVIA data, respectively. The prices were adjusted to estimate the ex-factory prices using the discount/rebate rate suggested by the Health Insurance Review Agency (HIRA). The four price indices of Laspeyres, Paasche, Fisher, and the unweighted index were calculated using the price in each country, the average price, and lowest price among the study countries. Each currency was converted using the currency exchange rate and purchasing power parity (PPP). The budget impact of implementing the proposed pre-listing and post-evaluation scheme on payers was calculated.

resultsBased on the currency exchange rate, anticancer drug prices were higher in other countries (index range: 1.05-2.78) compared to Korea. The prices in Korea were similar to countries with the lowest prices. When the PPP was applied, prices were higher in the US, Germany, Italy, and Japan than in Korea (range: 1.10-2.13); however, the prices were lower in the UK, France, and Switzerland than in Korea (range: 0.72-0.99). The financial burden of implementing the pre-listing and post-evaluation scheme was calculated at 0.83% of the total anticancer drug sales value in Korea from 2013-2017.

conclusionsThe prices of anticancer drugs in Korea were similar to the lowest prices among the seven other study countries. A pre-listing and post-evaluation scheme should be considered to improve patient access to novel anticancer drugs by reducing the reimbursement review time and uncertainties.

Indexed as

Antineoplastic AgentsDrug CostsFranceGermanyHumansItalyJapanRepublic of KoreaSwitzerlandAntineoplastic Agentsanticancer drugsinternational pricepatient accessprice comparisonprice index

Identifiers

PMID33466893
PMCPMC7830510
OpenAlexW3119980934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.