ReviewInternational journal of environmental research and public health2021
Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System.
Review in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed, 2 syntheses or guidelines pooled it, 216 citations in OpenAlex.
- Effectiveness and safety of continuous subcutaneous hydrocortisone infusion in managing adrenocortical insufficiency in adult patients: a systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- The Influence of Ketone Bodies on Circadian Processes Regarding Appetite, Sleep and Hormone Release: A Systematic Review of the Literature.Nutrients · 2022Pooled it
- A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men.Scientific reports · 2023Trial
- The Dangerous Liaison Between Depression and Cardiovascular Disease: A Narrative Review of Epidemiology, Mechanisms, and Clinical Management.Journal of clinical medicine · 2026Review
- Stress-related salivary biomarkers - cortisol, dehydroepiandrosterone, alpha amylase, and suicidal ideation among young women living in Kampala's informal settlements.Social psychiatry and psychiatric epidemiology · 2026Article
- Predictive Value of FT3/FT4 and Neutrophil-to-Lymphocyte Ratios for Post-Ischemic Stroke Urinary Tract Infection and Their Association With Longitudinal Functional Recovery Trajectories: A Retrospective Cohort Study.Brain and behavior · 2026Article
- Dietary acid load and oxidative stress in relation to sleep quality and duration among Iranian adults.Scientific reports · 2026Article
- Diurnal Variations and Test-Retest Reliability of Resting-State Functional MRI Metrics.Human brain mapping · 2026Article
- Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- The mediating role of sleep quality in the association between job stress and quality of life among medical university employees.Scientific reports · 2026Article
- Vitamin C mitigates thermal stress-induced oxidative imbalance and cortisol elevation in Wistar rats.Biologia futura · 2026Article
- Challenges of after-hours pediatric imaging.Pediatric radiology · 2026Review
- Circadian troponin dynamics reveal sex-specific signals for acute coronary syndrome evaluation.Internal and emergency medicine · 2026Article
- Cortisol Stability at 16 and 30 Years in Urine Specimens Stored at -20°C.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- The Rate of Cortisol Decline After Consuming a High-Fat Test Meal for Breakfast Partially Explained Sex-Dependent Variation in Post Ingestive Cardiovascular Status.Current developments in nutrition · 2026Article
- Time management and academic achievement among medical students: a cross-sectional study.BMC medical education · 2026Article
- Circadian patterns of patient symptoms in a tertiary university emergency department: a single-centre retrospective analysis.BMJ open · 2026Article
- Viewing art as a pathway to psychological well-being and physical health.Applied psychology. Health and well-being · 2026Article
- Travel-Related Changes in Physiological Health Markers: The Effects of Transmeridian Travel on Female Volleyball Players.International journal of exercise science · 2026Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The synthesis and secretion of cortisol are controlled by the hypothalamic-pituitary-adrenal axis. Cortisol exhibits a proper 24-h circadian rhythm that affects the brain, the autonomic nervous system, the heart, and the vasculature that prepares the cardiovascular system for optimal function during these anticipated behavioral cycles. A literature search was conducted using databases such as Google Scholar, PubMed, and Scopus. Relevant search terms included "circadian rhythm and cardiovascular", "cortisol", "cortisol and acute coronary syndrome", "cortisol and arrhythmias", "cortisol and sudden cardiac death", "cortisol and stroke", and "cardioprotective agents". A total of 120 articles were obtained on the basis of the above search. Lower levels of cortisol were seen at the beginning of sleep, while there was a rise towards the end of sleep, with the highest level reached at the moment the individual wakes up. In the present review, we discuss the role of 11β-hydroxysteroid dehydrogenase (11β-HSD1), which is a novel molecular target of interest for treating metabolic syndrome and type-2 diabetes mellitus. 11β-HSD1 is the major determinant of cortisol excess, and its inhibition alleviates metabolic abnormalities. The present review highlights the role of cortisol, which controls the circadian rhythm, and describes its effect on the cardiovascular system. The review provides a platform for future potential cardioprotective therapeutic agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.