Evidence map›Paper›PMID 33466825›Full record

ArticleInternational journal of molecular sciences2021

A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Guèrin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-α.

Kazuko Tajiri, Kyoko Imanaka-Yoshida, Yusuke Tsujimura, Kazuhiro Matsuo, Michiaki Hiroe, Kazutaka Aonuma, Masaki Ieda, Yasuhiro Yasutomi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Combination ofExperimental and therapeutic medicine · 2022
    Article
  3. Article
  4. Tenascin-C in Heart Diseases-The Role of Inflammation.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Kazuko TajiriTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba 305-0843, Japan.ORCID 0000-0002-9759-1008
Kyoko Imanaka-YoshidaDepartment of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Yusuke TsujimuraTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba 305-0843, Japan.
Kazuhiro MatsuoDepartment of Research and Development, Japan BCG Laboratory, Kiyose 204-0022, Japan.
Michiaki HiroeDepartment of Cardiology, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Kazutaka AonumaDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Masaki IedaDepartment of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.ORCID 0000-0003-4724-3299
Yasuhiro YasutomiTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Tsukuba 305-0843, Japan.
University of Tsukuba · JPJapan BCG Laboratory · JPMie University · JPNational Center for Global Health and Medicine · JPNational Institute of Biomedical Innovation, Health and Nutrition · JPNational Institute of Infectious Diseases · JP

Funding

Japan Society for the Promotion of Science 25860581 and 20K08396
6 · The paper itself

Abstract

Dilated cardiomyopathy (DCM) is a potentially lethal disorder characterized by progressive impairment of cardiac function. Chronic myocarditis has long been hypothesized to be one of the causes of DCM. However, owing to the lack of suitable animal models of chronic myocarditis, its pathophysiology remains unclear. Here, we report a novel mouse model of chronic myocarditis induced by recombinant bacille Calmette-Guérin (rBCG) expressing a CD4

Indexed as

Disease Models, AnimalAnimalsBCG VaccineCardiomyopathy, DilatedChronic DiseaseCytokinesEchocardiographyEpitopes, T-LymphocyteHumansInterleukin-17Lymphocyte ActivationMaleMiceMice, Inbred BALB CMyocarditisRecombinant ProteinsBCG VaccineCytokinesEpitopes, T-LymphocyteInterleukin-17Recombinant ProteinsVentricular Myosinsautoimmune myocarditisautoimmunityBCGinflammatory dilated cardiomyopathymyocarditisrecombinant BCG

Identifiers

PMID33466825
PMCPMC7829923
OpenAlexW3119223318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.