Evidence map›Paper›PMID 33466746›Full record

ReviewNutrients2021

Non-IgE- or Mixed IgE/Non-IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis.

Mauro Calvani, Caterina Anania, Barbara Cuomo, Enza D'Auria, Fabio Decimo, Giovanni Cosimo Indirli, Gianluigi Marseglia, Violetta Mastrorilli, Marco Ugo Andrea Sartorio, Angelica Santoro and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 79 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  9. Observational
  10. Review
  11. Article
  12. Observational
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Lymphocyte stimulation test for diagnosing hen's egg yolk-induced enterocolitis syndrome.The journal of allergy and clinical immunology. Global · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 1 country.

Mauro CalvaniOperative Unit of Pediatrics, S. Camillo-Forlanini Hospital, 00152 Rome, Italy.ORCID 0000-0001-7223-9692
Caterina AnaniaImmunology and Allergology Unit, Department of Mother-Child, Urological Science, Sapienza University of Rome, 00161 Rome, Italy.
Barbara CuomoOperative Complex Unit of Pediatrics, Belcolle Hospital, 00100 Viterbo, Italy.
Enza D'AuriaDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, 20154 Milan, Italy.
Fabio DecimoDepartment of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Giovanni Cosimo IndirliPediatrician and Allergoimmunologist, Regional Coordinator of the Italian Society of Pediatric Allergology and Immunology (SIAIP) for Regions Puglia and Basilicata, 73100 Lecce, Italy.
Gianluigi MarsegliaPediatric Clinic, Pediatrics Department, Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy.
Violetta MastrorilliOperative Complex Unit of Pediatrics and Emergency, Giovanni XXIII Hospital, 70056 Bari, Italy.
Marco Ugo Andrea SartorioDepartment of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, 20154 Milan, Italy.
Angelica SantoroPediatric Clinic, Mother-Child Department, University of Parma, 43121 Parma, Italy.
Elisabetta VeronelliFood Allergy Committee of the Italian Society of Pediatric Allergy and Immunology (SIAIP), Pediatric Department, Garbagnate Milanese Hospital, ASST Rhodense, 70056 Garbagnate Milanese, Italy.
University of Milan · ITAziende Socio Sanitaria Territoriale RhodenseCarlo Forlanini Hospital · ITOspedale di Belcolle · ITOspedale Pediatrico Giovanni XXIII · ITRegione Puglia · ITSapienza University of Rome · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Parma · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergen-specific lymphocyte stimulation test (ALST) and clinical score (CoMiss).

Indexed as

Immunologic TestsEnteritisEosinophiliaEosinophilic EsophagitisFecesFood HypersensitivityGastritisGastrointestinal DiseasesHumansImmunoglobulin EImmunoglobulin Eallergen-specific lymphocyte stimulation testatopy patch testclinical scoreendoscopyeosinophilic gastrointestinal disordersfecal biomarkersIgG and IgG4non-IgE gastrointestinal food allergyoral food challenge

Identifiers

PMID33466746
PMCPMC7829867
OpenAlexW3119371119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.