Evidence map›Paper›PMID 33466541›Full record

ArticleMarine drugs2021

Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings.

Lexin Long, Ruojun Wang, Ho Yin Chiang, Wei Ding, Yong-Xin Li, Feng Chen, Pei-Yuan Qian

Abstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lexin LongSZU-HKUST Joint PhD Program in Marine Environmental Science, Shenzhen University, Shenzhen 518000, China.ORCID 0000-0002-6350-4287
Ruojun WangDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.ORCID 0000-0002-2399-7080
Ho Yin ChiangDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.
Wei DingColleague of Marine Life Science, Ocean University of China, 5 Yushan Road, Qingdao 266100, China.
Yong-Xin LiDepartment of Chemistry, The University of Hong Kong, Pokfulam, Hong Kong 999077, China.ORCID 0000-0003-4422-2302
Feng ChenInstitute for Advanced Study, Shenzhen University, Shenzhen 518060, China.
Pei-Yuan QianDepartment of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.

Funding

China Ocean Mineral Resources Research and Development Association COMRRDA17SC01HKSAR government C6026-19G-AHong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) GML2019ZD0409Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) SMSEGL20SC01National Key R&D Program of China 2018YFA0903200
6 · The paper itself

Abstract

Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a screening program of antibiofilm compounds against marine biofilms, we discovered the potent biofilm inhibitory activity of elasnin. Elasnin effectively inhibited the biofilm formation of seven strains of bacteria isolated from marine biofilms. With high productivity, elasnin-based coatings were prepared in an easy and cost-effective way, which exhibited great performance in inhibiting the formation of multi-species biofilms and the attachment of large biofouling organisms in the marine environment. The 16S amplicon analysis and anti-larvae assay revealed that elasnin could prevent biofouling by the indirect impact of changed microbial composition of biofilms and direct inhibitory effect on larval settlement with low toxic effects. These findings indicated the potential application of elasnin in biofilm and biofouling control in the marine environment.

Indexed as

Aquatic OrganismsBiofilmsBiofoulingDose-Response Relationship, DrugMicrobial Sensitivity TestsPyronesStaphylococcus aureusStreptomyceselasninPyronesbiofilmsbiofoulingelasninmarinenatural products

Identifiers

PMID33466541
PMCPMC7824865

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.