Evidence map›Paper›PMID 33466524›Full record

ArticleToxins2021

BmK NSPK, a Potent Potassium Channel Inhibitor from Scorpion

Fang Zhao, Xiaohan Zou, Shaoheng Li, Jing He, Chuchu Xi, Qinglian Tang, Yujing Wang, Zhengyu Cao

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fang ZhaoDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Xiaohan ZouDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Shaoheng LiDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Jing HeDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Chuchu XiDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Qinglian TangDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yujing WangDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Zhengyu CaoDepartment of TCM Pharmacology, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
China Pharmaceutical University · CN

Funding

China Postdoctoral Science Foundation 2018M630645China Postdoctoral Science Foundation 2018M642371National Science and Technology Major Projects for Major New Drugs Innovation and Development 2018ZX09101003-004-002the National Natural Science Foundation of China 21777192the National Natural Science Foundation of China 81473539the National Natural Science Foundation of China 81903826the National Natural Science Foundation of China 81972960
6 · The paper itself

Abstract

Scorpion toxins represent a variety of tools to explore molecular mechanisms and cellular signaling pathways of many biological functions. These toxins are also promising lead compounds for developing treatments for many neurological diseases. In the current study, we purified a new scorpion toxin designated as BmK NSPK (

Indexed as

Amino Acid SequenceAnimalsCalciumCalcium SignalingIndolesMiceMice, Inbred C57BLNerve Growth FactorNeuronal OutgrowthNeuronsPeptidesPhosphorylationPotassium Channel BlockersPotassium ChannelsProto-Oncogene Proteins c-aktReceptor, trkACalciumGW 441756IndolesNerve Growth FactorPeptidesPotassium Channel BlockersPotassium ChannelsProto-Oncogene Proteins c-aktReceptor, trkAScorpion Venomsnerve growth factorneurite outgrowthpotassium channelscorpion toxin

Identifiers

PMID33466524
PMCPMC7824859
OpenAlexW3120420465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.