Evidence map›Paper›PMID 33466522›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Lab-on-Microsphere-FRET-Based Multiplex Sensor Platform.

Vera Kuznetsova, Viktoria Osipova, Anton Tkach, Maksim Miropoltsev, Danil Kurshanov, Anastasiia Sokolova, Sergei Cherevkov, Viktor Zakharov, Anatoly Fedorov, Alexander Baranov and 1 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Multimodal Magnetic Nanoparticle-Quantum Dot Composites.Nanomaterials (Basel, Switzerland) · 2025
    Article
  3. Synthesis of Submicron CaCOMicromachines · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vera KuznetsovaCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.ORCID 0000-0001-6824-3349
Viktoria OsipovaCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Anton TkachCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Maksim MiropoltsevCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Danil KurshanovCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Anastasiia SokolovaCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Sergei CherevkovCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.ORCID 0000-0002-9466-4558
Viktor ZakharovCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Anatoly FedorovCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Alexander BaranovCenter of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.
Yurii Gun'koChemistry School, Trinity College Dublin, 2 Dublin, Ireland.ORCID 0000-0002-4772-778X

Funding

Ministry of Science and Higher Education of the Russian Federation 14.587.21.0047, identifier RFMEFI58718X0047
6 · The paper itself

Abstract

Here we report on the development and investigation of a novel multiplex assay model based on polymer microspheres (PMS) encoded with ternary AIS/ZnS quantum dots (QDs). The system was prepared via layer-by-layer deposition technique. Our studies of Förster resonance energy transfer (FRET) between the QD-encoded microspheres and two different cyanine dyes have demonstrated that the QD photoluminescence (PL) quenching steadily increases with a decrease in the QD-dye distance. We have found that the sensitized dye PL intensity demonstrates a clear maximum at two double layers of polyelectrolytes between QDs and Dye molecules on the polymer microspheres. Time resolved PL measurements have shown that the PL lifetime decreases for the QDs and increases for the dyes due to FRET. The designed system makes it possible to record spectrally different bands of FRET-induced dye luminescence with different decay times and thereby allows for the multiplexing by wavelength and photoluminescence lifetimes of the dyes. We believe that PMS encoded with AIS/ZnS QDs have great potential for the development of new highly selective and sensitive sensor systems for multiplex analysis to detect cell lysates and body fluids' representative biomarkers.

Indexed as

AgInS2cyanine dyesFRETmicrospheressensingternary quantum dotstime-resolved fluorescence spectroscopy

Identifiers

PMID33466522
PMCPMC7824841

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.