Evidence map›Paper›PMID 33466426›Full record

ReviewDiagnostics (Basel, Switzerland)2021

Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines.

Andrea Bernetti, Francesco Agostini, Alessandro de Sire, Massimiliano Mangone, Lucrezia Tognolo, Annalisa Di Cesare, Pierangela Ruiu, Teresa Paolucci, Marco Invernizzi, Marco Paoloni

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06320938 (Comparison of the Effects of Neuroscience-Based Pain Education and Myofascial Induction Technique on Pain and Quality of Life in Patients With Chronic Neck Pain), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06320938 nacompletednot on this mapstarted 2024, after this paper: background citation

Comparison of the Effects of Neuroscience-Based Pain Education and Myofascial Induction Technique on Pain and Quality of Life in Patients With Chronic Neck Pain

TypeinterventionalSponsorTurkoglu Dr. Kemal Beyazit State HospitalRan2024 to 2025Enrolled60ConditionsCervical Spine DiseaseArmsNeuroscience-Based Pain Education Combined with Home Exercise Program, Myofascial Induction Techniques Combined with Home Exercise Program, Home Exercises Group
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Perioperative Treatment of Neuropathic Pain (Nerve SPACE 2025).Journal of hand surgery global online · 2026
    Article
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  15. Article
  16. Frontiers in pain research (Lausanne, Switzerland) · 2025
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Andrea BernettiDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.
Francesco AgostiniDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-3162-3473
Alessandro de SireDepartment of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0002-5541-8346
Massimiliano MangoneDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.
Lucrezia TognoloDepartment of Neurosciences, University of Padua, 35121 Padua, Italy.ORCID 0000-0002-4239-4859
Annalisa Di CesareDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.
Pierangela RuiuDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.
Teresa PaolucciDepartment of Medical and Oral Sciences and Biotechnologies, University of G. D'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-8694-1404
Marco InvernizziDepartment of Health Sciences, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0001-5141-0681
Marco PaoloniDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-0947-9711
Sapienza University of Rome · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Chieti-Pescara · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuropathic pain is an injury or disease of the central and/or peripheral somatosensory nervous system, and it has a significant impact on quality of life, especially since it is often refractory to treatment. Rehabilitative intervention is considered in various guidelines on neuropathic pain treatment, although not in an organic nor detailed way. The aim of this systematic review was to analyze the most indicated therapeutic strategies, providing rehabilitative recommendations in the management of neuropathic pain.

methodsA systematic review was performed according to PRISMA guidelines. The scientific search, carried out until July 2020, considered guidelines in English language of the last thirteen years.

resultsSix guidelines were analyzed, from which emerges that a multidisciplinary approach, comprehensive of pharmacologic and nonpharmacologic interventions, should drive neuropathic pain management. A relevant role in non-pharmacological intervention is played by rehabilitation, through an adequate tailored rehabilitation program and physical therapies.

conclusionThis analysis highlights the importance of rehabilitation but also the lack of evidence on various rehabilitative practices. Arises hence the need for further studies in this field to better define a rehabilitative treatment strategy.

Indexed as

guidelinesinstrumental physical therapyneuropathic painrecommendationrehabilitation

Identifiers

PMID33466426
PMCPMC7824970
OpenAlexW3118803137

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.