ArticleInternational journal of molecular sciences2021
Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the "Normobaric Oxygen Paradox".
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.Frontiers in neurology · 2025Pooled it
- Using the gross motor function measure evolution ratio to compare different dosage of hyperbaric treatment with conventional therapies in children with cerebral palsy - could it end the controversy?Frontiers in neurology · 2024Pooled it
- Perioperative Normobaric Hyperoxia Combined With Pulmonary Rehabilitation Intervention for Enhanced Short-Term Recovery in Lung Cancer Surgery.Thoracic cancer · 2026Trial
- Synergistic effects of immediate post-sprint interval training low-dose hyperbaric oxygen on aerobic and anaerobic performance and recovery indicators: a four-week randomized controlled trial.European journal of applied physiology · 2026Trial
- Effect of one session of hyperbaric oxygen (2.5 ATA for 60 min) after moderate-intensity exercise on fatigue: a single-blind crossover randomized trial.Frontiers in sports and active living · 2025Trial
- Oxidative Stress Response's Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures.International journal of molecular sciences · 2022Trial
- Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?International journal of molecular sciences · 2022Trial
- Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial.International journal of environmental research and public health · 2021Trial
- Optimizing Intermittent Hypoxic-Hyperoxic Training for Safety and Feasibility: An Exploratory Pilot Study.Journal of functional morphology and kinesiology · 2026Article
- Return to an extreme environment exposure after pulmonary infection: SCUBA diving as a model?Physiological reports · 2026Article
- Oxygen Variations, 2nd Edition: Integrative Insights from Cellular Models to Clinical Physiology.International journal of molecular sciences · 2026Article
- Induction of protective proteins is fundamental to hyperbaric oxygen preconditioning.Frontiers in cell and developmental biology · 2026Review
- Traditional Health Practices May Promote Nrf2 Activation Similar to Exercise.International journal of molecular sciences · 2025Review
- Impact of Five Weeks of Strengthening Under Blood Flow Restriction (BFR) or Supplemental Oxygen Breathing (Normobaric Hyperoxia) on the Medial Gastrocnemius.Journal of functional morphology and kinesiology · 2024Article
- Inert Gas Mild Pressure Action on Healthy Humans: The "IPA" Study.International journal of molecular sciences · 2024Article
- Decompression Illness After Technical Diving Session in Mediterranean Sea: Oxidative Stress, Inflammation, and HBO Therapy.International journal of molecular sciences · 2024Article
- Exploring the effects of post operative hyperoxic intermittent stimuli on reticulocyte levels in cancer patients: a randomized controlled study.Journal of anesthesia, analgesia and critical care · 2024Article
- Review
- Hyperbaric Oxygen Reduces Oxidative Stress Impairment and DNA Damage and Simultaneously Increases HIF-1α in Ischemia-Reperfusion Acute Kidney Injury.International journal of molecular sciences · 2024Article
- Pulsed Hyperoxia Acts on Plasmatic Advanced Glycation End Products and Advanced Oxidation Protein Products and Modulates Mitochondrial Biogenesis in Human Peripheral Blood Mononuclear Cells: A Pilot Study on the "Normobaric Oxygen Paradox".International journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The term "normobaric oxygen paradox" (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend of oxygen-sensitive transcription factors in human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects after one hour of exposure to mild (MH), high (HH) and very high (VHH) hyperoxia, corresponding to 30%, 100%, 140% O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.