Evidence map›Paper›PMID 33466402›Full record

ArticleCancers2021

Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer.

Pankaj Ahluwalia, Meenakshi Ahluwalia, Ashis K Mondal, Nikhil Sahajpal, Vamsi Kota, Mumtaz V Rojiani, Amyn M Rojiani, Ravindra Kolhe

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. The Current Roadmap of Lung Cancer Biology, Genomics and Racial Disparity.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. Identification of a TIGIT-expressing CD8Frontiers in immunology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. ANXA5: A Key Regulator of Immune Cell Infiltration in Hepatocellular Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pankaj AhluwaliaDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Meenakshi AhluwaliaDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Ashis K MondalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Nikhil SahajpalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Vamsi KotaDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-5290-9289
Mumtaz V RojianiDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-0597-9305
Amyn M RojianiDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-5621-3724
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8283-2403

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is one of the leading causes of death worldwide. Cell death pathways such as autophagy, apoptosis, and necrosis can provide useful clinical and immunological insights that can assist in the design of personalized therapeutics. In this study, variations in the expression of genes involved in cell death pathways and resulting infiltration of immune cells were explored in lung adenocarcinoma (The Cancer Genome Atlas: TCGA, lung adenocarcinoma (LUAD), 510 patients). Firstly, genes involved in autophagy (

Indexed as

apoptosiscell deathgene expressionimmunotherapyLUADlung cancernecrosisprognostic genestumor microenvironment

Identifiers

PMID33466402
PMCPMC7795632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.