ReviewMolecules (Basel, Switzerland)2021
Thermal Stability of Amorphous Solid Dispersions.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
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Who cites it
21 citing papers in PubMed.
- Formulation Strategies to Enhance the Solubility of Poorly Water-Soluble Drugs and Phytochemicals: Current Advances and Challenges.Pharmaceutics · 2026Review
- Tabletting of single-screw hot melt extruded itraconazole: HPMC-AS amorphous solid dispersion by 3D printing and direct compression.Drug delivery and translational research · 2026Article
- Thermal and Kinetic Analysis of Benzimidazole Derivatives: Fenbendazole, Mebendazole, and Flubendazole.Molecules (Basel, Switzerland) · 2026Article
- Assessing the Impact of Mesoporous, Co-Amorphous, and Polymer-Based Systems on Cefdinir's Dissolution and Stability Via Predictive Modeling.British journal of biomedical science · 2026Article
- Differential Scanning Calorimetry (DSC) in Solid-State Characterization of Solid Dispersions: A Practical Guide.AAPS PharmSciTech · 2025Review
- Investigation of Fenbendazole Solubility Using Particle Size Reduction Methods in the Presence of SoluplusPharmaceutics · 2025Article
- Continuous Processing Strategies for Amorphous Solid Dispersions of Itraconazole: Impact of Polymer Selection and Manufacturing Techniques.Pharmaceutics · 2025Article
- Application of Theoretical Solubility Calculations and Thermal and Spectroscopic Measurements to Guide the Processing of Triamcinolone Acetonide by Hot-Melt Extrusion.Pharmaceutics · 2025Article
- An Investigation into the Effect of Maltitol, Sorbitol, and Xylitol on the Formation of Carbamazepine Solid Dispersions Through Thermal Processing.Pharmaceutics · 2025Article
- Sustainable and biocompatible hybrid materials-based sulfated polysaccharides for biomedical applications: a review.RSC advances · 2025Review
- Recent Patents on Solid Dispersions Emphasize Promising Benefits in Solubility Enhancement of Poorly Water-soluble Drugs.Recent patents on nanotechnology · 2025Review
- Data-Driven Design of Novel Polymer Excipients for Pharmaceutical Amorphous Solid Dispersions.Bioconjugate chemistry · 2024Article
- Investigating the Influence of Processing Conditions on Dissolution and Physical Stability of Solid Dispersions with Fenofibrate and Mesoporous Silica.Pharmaceutics · 2024Article
- Emerging Applications of Hydroxypropyl Methylcellulose Acetate Succinate: Different Aspects in Drug Delivery and Its Commercial Potential.AAPS PharmSciTech · 2023Review
- Transition Metal-Decorated BACS omega · 2023Article
- Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions-The Effect of Different Types of Polymers.Pharmaceutics · 2023Article
- Cyclosporine A-Loaded Ternary Solid Dispersion Prepared with Fine Droplet Drying Process for Improvement of Storage Stability and Oral Bioavailability.Pharmaceutics · 2023Article
- Characterization and Antibacterial Evaluation of Biodegradable Mannose-Conjugated Fe-MIL-88NHPolymers · 2022Article
- Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions.Pharmaceutics · 2021Article
- Thermal Stability Kinetics and Shelf Life Estimation of the Redox-Active Therapeutic and Mimic of Superoxide Dismutase Enzyme, Mn(III)Oxidative medicine and cellular longevity · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs. One of the major keys for successful preparation of ASD is the selection of appropriate excipients, mostly polymers, which have a crucial role in improving drug solubility and its physical stability. Even though, excipients should be chemically inert, there is some evidence that polymers can affect the thermal stability of active pharmaceutical ingredients (API). The thermal stability of a drug is closely related to the shelf-life of pharmaceutical products and therefore it is a matter of high pharmaceutical relevance. An overview of thermal stability of amorphous solids is provided in this paper. Evaluation of thermal stability of amorphous solid dispersion is perceived from the physicochemical perspective, from a kinetic (motions) and thermodynamic (energy) point of view, focusing on activation energy and fragility, as well all other relevant parameters for ASD design, with a glance on computational kinetic analysis of solid-state decomposition.
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