Evidence map›Paper›PMID 33466305›Full record

Observational studyGenes2021

Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study.

Eleni M Loizidou, Anastasia Kucherenko, Pavlo Tatarskyy, Sergey Chernushyn, Ganna Livshyts, Roman Gulkovskyi, Iryna Vorobiova, Yurii Antipkin, Oleksandra Gorodna, Marika A Kaakinen and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Unlocking Implantation: The Role of Nitric Oxide, NOInternational journal of molecular sciences · 2025
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Genes · 2021
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Eleni M LoizidouSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.
Anastasia KucherenkoInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Pavlo TatarskyyInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Sergey ChernushynInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Ganna LivshytsInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Roman GulkovskyiInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Iryna VorobiovaInstitute of Paediatrics, Obstetrics and Gynaecology of the National Academy of Medical Sciences, 04050 Kiev, Ukraine.
Yurii AntipkinInstitute of Paediatrics, Obstetrics and Gynaecology of the National Academy of Medical Sciences, 04050 Kiev, Ukraine.
Oleksandra GorodnaInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Marika A KaakinenSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.
Inga ProkopenkoSection of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London W12 0NN, UK.
Ludmila LivshitsInstitute of Molecular Biology and Genetics NAS, 03143 Kiev, Ukraine.
Institute of Molecular Biology and Genetics · UAUniversity of Surrey · GBImperial College London · GB

Funding

Wellcome Trust WT205915/Z/17/Z
6 · The paper itself

Abstract

We assessed the predictive ability of a combined genetic variant panel for the risk of recurrent pregnancy loss (RPL) through a case-control study. Our study sample was from Ukraine and included 114 cases with idiopathic RPL and 106 controls without any pregnancy losses/complications and with at least one healthy child. We genotyped variants within 12 genetic loci reflecting the main biological pathways involved in pregnancy maintenance: blood coagulation (

Indexed as

Genetic Predisposition to DiseaseAbortion, HabitualAdultCase-Control StudiesFemaleGenotyping TechniquesHumansPolymorphism, Single NucleotidePredictive Value of TestsPregnancyRisk AssessmentROC CurveUkrainegenetic risk scorerecurrent pregnancy loss

Identifiers

PMID33466305
PMCPMC7824779
OpenAlexW3120136941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.