ArticleActa obstetricia et gynecologica Scandinavica2021
Uptake of fetal aneuploidy screening after the introduction of the non-invasive prenatal test: A national population-based register study.
Article in Acta obstetricia et gynecologica Scandinavica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Perspectives on Fetal Sex and Prenatal Diagnosis of Differences of Sex Development Among Midwives.Prenatal diagnosis · 2025Article
- Comparing the Introduction and Implementation of Noninvasive Prenatal Testing (NIPT) in Japan, the Netherlands, and the United States: An Integrative Review.Prenatal diagnosis · 2025Review
- Uptake rates for non-invasive prenatal screening for single-gene disorders associated with advanced paternal age.Journal of genetic counseling · 2025Article
- Article
- Prenatal cell-free DNA testing of women with pregnancy-associated cancer: a retrospective cross-sectional study.The Lancet regional health. Europe · 2024Article
- Primary care professionals' views on population-based expanded carrier screening: an online focus group study.Family practice · 2024Article
- Article
- Informed choice and routinization of the second-trimester anomaly scan: a national cohort study in the Netherlands.BMC pregnancy and childbirth · 2023Article
- Non-Invasive Prenatal Testing (NIPT): Reliability, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Population monitoring of trisomy 21: problems and approaches.Molecular cytogenetics · 2023Review
- Non-invasive prenatal testing in Germany: a unique ethical and policy landscape.European journal of human genetics : EJHG · 2023Article
- Additional value of advanced ultrasonography in pregnancies with two inconclusive cell-free DNA draws.Prenatal diagnosis · 2022Article
- Timing of diagnosis of fetal structural abnormalities after the introduction of universal cell-free DNA in the absence of first-trimester anatomical screening.Prenatal diagnosis · 2022Article
- Nationwide implementation of the non-invasive prenatal test: Evaluation of a blended learning program for counselors.PloS one · 2022Article
- Effect of prenatal screening on trends in perinatal mortality associated with congenital anomalies before and after the introduction of prenatal screening: A population-based study in the Northern Netherlands.Paediatric and perinatal epidemiology · 2021Article
- Non-invasive prenatal test uptake in socioeconomically disadvantaged neighborhoods.Prenatal diagnosis · 2021Article
- Does non-invasive prenatal testing affect the livebirth prevalence of Down syndrome in the Netherlands? A population-based register study.Prenatal diagnosis · 2021Article
- Uptake of fetal aneuploidy screening after the introduction of the non-invasive prenatal test: A national population-based register study.Acta obstetricia et gynecologica Scandinavica · 2021Article
- Isolated Increased Nuchal Translucency in First Trimester Ultrasound Scan: Diagnostic Yield of Prenatal Microarray and Outcome of Pregnancy.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe introduction of the non-invasive prenatal test (NIPT) has shifted the prenatal screening landscape. Countries are exploring ways to integrate NIPT in their national prenatal screening programs, either as a first- or second-tier test. This study aimed to describe how the uptake of fetal aneuploidy screening changed after the introduction of NIPT as a second-tier and as a first-tier test within the national prenatal screening program of the Netherlands. MATERIAL AND
methodsA population-based register study in the Netherlands, recording uptake of fetal aneuploidy screening. Data from all pregnant women choosing to have the first-trimester combined test (FCT) or first-tier NIPT between January 2007 and March 2019 were retrospectively collected using national registration systems. Uptake percentages for fetal aneuploidy screening (FCT and NIPT) were calculated and stratified by region and maternal age. Statistical significance was determined using trend analysis and chi-squared tests.
resultsBetween 2007 and 2013 FCT uptake increased from 14.8% to 29.5% (P = .004). In April 2014 NIPT was introduced as a second-tier test for high-risk women after FCT (TRIDENT-1 study). FCT uptake rose from 29.5% in 2013 to 34.2% in 2015 (P < .0001). After the introduction of NIPT as a first-tier test for all women in April 2017 (TRIDENT-2 study), FCT uptake declined significantly from 35.8% in 2016 to 2.6% in 2018 (P < .0001). NIPT uptake increased to 43.4% in 2018. Regionally, NIPT uptake ranged from 31.8% to 67.9%. Total uptake (FCT and NIPT) between 2007 and 2018 increased significantly from 14.8% to 45.9% (P < .0001). However, total uptake stabilized at 46% for both years of TRIDENT-2 (April 2017-March 2019).
conclusionsAn increase in total fetal aneuploidy screening uptake up to 45.9% was observed after the introduction of NIPT. Uptake appears to have stabilized within a year after introducing first-tier NIPT.
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