Evidence map›Paper›PMID 33465697›Full record

ArticleLung cancer (Amsterdam, Netherlands)2021

Loss of wild type KRAS in KRAS

Yan Liu, Galen F Gao, John D Minna, Noelle S Williams, Kenneth D Westover

Abstract read
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
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  6. Article
  7. Emerging targets in lipid metabolism for cancer therapy.Trends in pharmacological sciences · 2024
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yan LiuDepartments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, United States.
Galen F GaoSchool of Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, United States.
John D MinnaHamon Center for Therapeutic Oncology Research, Departments of Internal Medicine and Pharmacology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, Texas, 75390-8593, United States.
Noelle S WilliamsDepartment of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, United States.
Kenneth D WestoverDepartments of Biochemistry and Radiation Oncology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, 75390, United States. Electronic address: kenneth.westover@utsouthwestern.edu.

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7M
Characterization and targeting of rapid nucleotide exchange RAS mutationsR01CA244341 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WESTOVER, KENNETH · 2020 to 2024
$1.8M
NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA244341
6 · The paper itself

Abstract

objectivesWild type RAS (RAS MATERIALS AND

methodsWe evaluated for associations between LAKR and cancer mortality in patients with KRAS

results24 % of patients with KRAS

conclusionsLAKR in KRAS

Indexed as

Adenocarcinoma of LungLung NeoplasmsFatty Acid SynthasesFatty Acid Synthase, Type IHumansMutationProspective StudiesProto-Oncogene Proteins p21(ras)FASN protein, humanFatty Acid SynthasesFatty Acid Synthase, Type IKRAS protein, humanProto-Oncogene Proteins p21(ras)KRASloss of heterozygosityLung adenocarcinomaRAS

Identifiers

PMID33465697
PMCPMC7897317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.