Evidence map›Paper›PMID 33465605›Full record

ArticleDrug and alcohol dependence2021

Hepatitis C virus infection and polysubstance use among young adult people who inject drugs in a rural county of New Mexico.

Katherine Wagner, Yuna Zhong, Eyasu Teshale, Kirsten White, Erin L Winstanley, Jennifer Hettema, Karla Thornton, Birgitta Bisztray, Philip Fiuty, Kimberly Page

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Katherine WagnerDepartment of Internal Medicine, MSC10 5550, 1 University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 84131, USA.
Yuna ZhongDivision of Viral Hepatitis, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Eyasu TeshaleDivision of Viral Hepatitis, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Kirsten WhiteDepartment of Internal Medicine, MSC10 5550, 1 University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 84131, USA.
Erin L WinstanleyDepartment of Behavioral Medicine and Psychiatry, School of Medicine and Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Jennifer HettemaDepartment of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Karla ThorntonDepartment of Internal Medicine, MSC10 5550, 1 University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 84131, USA; ECHO Institute University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Birgitta BisztrayDepartment of Internal Medicine, MSC10 5550, 1 University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 84131, USA.
Philip FiutyThe Mountain Center, Espanola, New Mexico, USA.
Kimberly PageDepartment of Internal Medicine, MSC10 5550, 1 University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, 84131, USA. Electronic address: pagek@salud.unm.edu.
University of New Mexico · USCenters for Disease Control and Prevention · USWest Virginia University · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Epidemiology, Prevention and Treatment of HCV in Young Adult Persons who Inject Drugs in non-urban New MexicoU18PS004568 · PS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI PAGE, KIMBERLY · 2014 to 2016
$900k
ACL HHS U18PS004568NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR001449NCHHSTP CDC HHS U18 PS004568
6 · The paper itself

Abstract

aimsWe assessed prevalence and correlates for hepatitis C virus (HCV) infection in young adult people who inject drugs (PWID) in rural New Mexico, where opioid use has been historically problematic.

methodsParticipants were 18-29 years old with self-reported injection drug use in the past 90 days. We conducted testing for HCV antibodies (anti-HCV) and HCV ribonucleic acid (RNA) and assessed sociodemographic and risk exposures. We provided counseling and referrals to prevention services and drug treatment. We estimated prevalence ratios (PR) to assess bivariate associations with HCV infection; and adjusted PRs using modified Poisson regression methods.

resultsAmong 256 participants tested for anti-HCV, 156 (60.9 %) had been exposed (anti-HCV positive), and of 230 tested for both anti-HCV and HCV RNA, 103 (44.8 %) had current infection (RNA-positive). The majority (87.6 %) of participants were Hispanic. Almost all (96.1 %) had ever injected heroin; 52.4 % and 52.0 % had ever injected methamphetamine or cocaine, respectively. Polysubstance injecting (heroin and any other drug) was associated with significantly higher prevalence of HCV infection (76.0 %) compared to injecting only heroin (24.0 %) (PR: 3.17 (95 % CI:1.93, 5.23)). Years of injecting, history of non-fatal opioid-involved overdose, polysubstance injecting, and stable housing were independently associated with HCV infection.

conclusionsHCV is highly prevalent among young adult PWID in rural NM. The high reported prevalence of polysubstance injecting and its association with HCV infection should be considered in prevention planning.

Indexed as

AdolescentAdultFemaleHepacivirusHepatitis CHepatitis C AntibodiesHeroinHumansMaleNew MexicoOpioid-Related DisordersPharmaceutical PreparationsPrevalenceRisk FactorsRural PopulationSubstance Abuse, IntravenousHepatitis C AntibodiesHeroinPharmaceutical PreparationsHCVHepatitisInjection drug useNew MexicoRuralYoung adults

Identifiers

PMID33465605
PMCPMC7889731
OpenAlexW3118307680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.