ArticleExperimental eye research2021
Piezo1 plays a role in optic nerve head astrocyte reactivity.
Article in Experimental eye research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.Journal of neuroinflammation · 2026Review
- Role of Piezo1 Channels Expressed in PVN in Regulating Sympathetic Nerve Activity and Arterial Blood Pressure in Rats.International journal of molecular sciences · 2026Article
- Swelling-induced calcium signaling in wild-type andFrontiers in cellular neuroscience · 2026Article
- Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates.Journal of neural engineering · 2025Article
- Pericytes in the optic nerve head.Progress in retinal and eye research · 2025Review
- Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway.Discover oncology · 2025Article
- Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis.Materials today. Bio · 2025Article
- Mechanosensitive ion channels in glaucoma pathophysiology.Vision research · 2024Review
- Mechanobiological Modulation ofACS biomaterials science & engineering · 2024Article
- Piezo1: the key regulators in central nervous system diseases.Frontiers in cellular neuroscience · 2024Review
- Mechanosensitive ion channel gene survey suggests potential roles in primary open angle glaucoma.Scientific reports · 2023Article
- Mechanical properties of the brain: Focus on the essential role of Piezo1-mediated mechanotransduction in the CNS.Brain and behavior · 2023Review
- Review
- Dimensionality-Dependent Mechanical Stretch Regulation of Cell Behavior.ACS applied materials & interfaces · 2022Article
- Mechanical Stretch Triggers Epithelial-Mesenchymal Transition in Keratinocytes Through Piezo1 Channel.Frontiers in physiology · 2022Article
- Mechanosensitive channel inhibition attenuates TGFβ2-induced actin cytoskeletal remodeling and reactivity in mouse optic nerve head astrocytes.Experimental eye research · 2021Article
- Reactive Astrocytes in Central Nervous System Injury: Subgroup and Potential Therapy.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Piezo1 (also known as Fam38A) is a mechanosensing channel required for mechanotransduction in various cell types. In astrocytes, Piezo1 activation is associated with the pathogenesis of central nervous system neurodegeneration. Expression of Piezo1 has been detected in mouse optic nerve head astrocytes, however, the functional role of Piezo1 has not been identified. In this study, we investigated the role of Piezo1 in optic nerve head astrocyte reactivity. Primary mouse optic nerve head astrocytes were cultured and subjected to mechanical stretch. The expression level of Piezo1 was determined by quantitative PCR and immunocytochemistry staining. Astrocytes were further treated with Yoda1, a specific Piezo1 agonist. The intracellular calcium concentration and expression of F-actin and fibronectin were determined in Yoda1 treated cells. We found that mechanical stretch activated Piezo1 in optic nerve head astrocytes. Yoda1 induced robust Ca
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Registered trials
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