Evidence map›Paper›PMID 33465336›Full record

ArticleJornal de pediatria

Protective effect of exclusive breastfeeding and effectiveness of maternal vaccination in reducing pertussis-like illness.

Renata Medeiros do Nascimento, Paulo Neves Baptista, Katiuscia Araújo de Miranda Lopes, Analíria Moraes Pimentel, Fábia da Silva Pereira Cruz, Ricardo Arraes de Alencar Ximenes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Exclusive Breastfeeding and Childhood Morbidity: A Narrative Review.International journal of environmental research and public health · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Renata Medeiros do NascimentoUniversidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brazil. Electronic address: medeiros_renata@hotmail.com.
Paulo Neves BaptistaUniversidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife, PE, Brazil.
Katiuscia Araújo de Miranda LopesUniversidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brazil.
Analíria Moraes PimentelUniversidade de Pernambuco, Hospital Universitário Oswaldo Cruz, Recife, PE, Brazil.
Fábia da Silva Pereira CruzSecretaria de Saúde do Estado de Pernambuco, Laboratório Central de Saúde de Pernambuco, Recife, PE, Brazil.
Ricardo Arraes de Alencar XimenesUniversidade de Pernambuco, Pós-Graduação em Ciências da Saúde, Recife, PE, Brazil.
Universidade de Pernambuco · BRHospital Universitário Oswaldo Cruz · BRSecretaria de Educação de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the protective effect of exclusive breastfeeding and the effectiveness of maternal vaccination in reducing pertussis-like illness.

methodThis was a case-control study conducted in sentinel hospitals for pertussis in Recife between July 2016 and July 2018. Cases included children aged under six months with symptoms compatible with pertussis (pertussis-like illness). Controls included children aged under six months, living in the metropolitan region of Recife with no diagnosis of pertussis-like illness and matched by the same hospital and birth date.

resultsSeventy-three cases and 194 controls were included. The diagnosis of pertussis-like illness was predominantly clinical (97,2%). Amongst the main symptoms, paroxysmal cough was observed in 95.89% of cases and vomiting in 53.4%. There were 29 hospitalized cases and no deaths. Out of the 73 cases, 47 were born to mothers vaccinated against pertussis during pregnancy, and the mothers of 144 of the 194 controls had been vaccinated. The protective effect of breastfeeding was of 74% (95% CI;38%, 89%). Children younger than six months, who were exclusively breastfed and with mothers vaccinated against pertussis during pregnancy were 5 times less likely to develop pertussis-like illness, corresponding to a protection of 79% (95% CI;31%, 94%). The effectiveness of maternal vaccination against pertussis-like illness in children under six months was low (27%) and not statistically significant (CI 95%; -34% a 60%).

conclusionsExclusive breastfeeding protects children under six months from pertussis-like illness and may be enhanced when associated with maternal vaccination. These strategies should be encouraged because they also protect against pertussis-like illnesses.

Indexed as

Breast FeedingWhooping CoughCase-Control StudiesChildFemaleHumansInfantMothersPregnancyVaccinationBreastfeedingDiphtheria, tetanus and acellular pertussis vaccineEffectivenessImmunizationPertussis

Identifiers

PMID33465336
PMCPMC9432170
OpenAlexW3122840323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.