ReviewAmerican journal of audiology2021
Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity.
Review in American journal of audiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Disproportionality analysis of drug-associated tinnitus safety signals: a 43-year pharmacovigilance study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Molecular remodeling of the central auditory pathway in tinnitus revealed by RNA sequencing.Genes & genomics · 2026Article
- Aspirin in Audiology: A Dual-Edged Sword in Hearing Loss and Its Nanotechnology-Driven Future.Drug design, development and therapy · 2026Review
- The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Candidate Key Proteins in Tinnitus-A Bioinformatic Study of Synaptic Transmission in the Inferior Colliculus.International journal of molecular sciences · 2025Article
- Drug-associated hearing impairment in children: a disproportionality analysis of the FDA adverse event reporting system.Frontiers in pharmacology · 2025Article
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Healthcare professionals' knowledge and practices in managing ototoxicity in children with cancer.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2024Article
- Thalamo-cortical neural mechanism of sodium salicylate-induced hyperacusis and anxiety-like behaviors.Communications biology · 2024Article
- Counseling Protocol for a Transitional Intervention for Debilitating Hyperacusis.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Background and Rationale for a Transitional Intervention for Debilitating Hyperacusis.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Article
- Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle.Frontiers in neuroscience · 2024Article
- Functional Connectivity Alterations and Molecular Characterization of the Anterior Cingulate Cortex in Tinnitus Pathology without Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Cortical evoked activity is modulated by the sleep state in a ferret model of tinnitus. A cross-case study.PloS one · 2024Article
- Influence of tinnitus, lifetime noise exposure, and firearm use on hearing thresholds, distortion product otoacoustic emissions, and their relative metric.The Journal of the Acoustical Society of America · 2023Article
- Longitudinal Study of Analgesic Use and Risk of Incident Persistent Tinnitus.Journal of general internal medicine · 2022Article
- Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats.Brain sciences · 2022Article
- Implications of Transcranial Magnetic Stimulation as a Treatment Modality for Tinnitus.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 3 countries.
Funding
Abstract
Purpose Tinnitus and hyperacusis are debilitating conditions often associated with age-, noise-, and drug-induced hearing loss. Because of their subjective nature, the neural mechanisms that give rise to tinnitus and hyperacusis are poorly understood. Over the past few decades, considerable progress has been made in deciphering the biological bases for these disorders using animal models. Method Important advances in understanding the biological bases of tinnitus and hyperacusis have come from studies in which tinnitus and hyperacusis are consistently induced with a high dose of salicylate, the active ingredient in aspirin. Results Salicylate induced a transient hearing loss characterized by a reduction in otoacoustic emissions, a moderate cochlear threshold shift, and a large reduction in the neural output of the cochlea. As the weak cochlear neural signals were relayed up the auditory pathway, they were progressively amplified so that the suprathreshold neural responses in the auditory cortex were much larger than normal. Excessive central gain (neural amplification), presumably resulting from diminished inhibition, is believed to contribute to hyperacusis and tinnitus. Salicylate also increased corticosterone stress hormone levels. Functional imaging studies indicated that salicylate increased spontaneous activity and enhanced functional connectivity between structures in the central auditory pathway and regions of the brain associated with arousal (reticular formation), emotion (amygdala), memory/spatial navigation (hippocampus), motor planning (cerebellum), and motor control (caudate/putamen). Conclusion These results suggest that tinnitus and hyperacusis arise from aberrant neural signaling in a complex neural network that includes both auditory and nonauditory structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.