ArticlePLoS neglected tropical diseases2021
Space-time risk cluster of visceral leishmaniasis in Brazilian endemic region with high social vulnerability: An ecological time series study.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Incidence of Human Visceral Leishmaniasis and Social Vulnerability in an Endemic Area of Northeastern Brazil: A Time Series Analysis.Epidemiologia (Basel, Switzerland) · 2026Article
- Social and environmental determinants of Neglected infectious diseases in quilombola communities of the Brazilian Amazon: An epidemiological and machine learning analysis.PLoS neglected tropical diseases · 2026Article
- Canine leishmaniasis in the Atlantic Rainforest Biome region of Bahia, Brazil, affected by deforestation: a one health perspective.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Article
- Temporal analysis and factors associated with visceral leishmaniasis-HIV-AIDS coinfection in an endemic region of Brazil.PLoS neglected tropical diseases · 2025Article
- Climatic, environmental, and social factors in Visceral Leishmaniasis: A spatio-temporal perspective in Brazilian biomes.PLoS neglected tropical diseases · 2025Article
- Spatiotemporal analysis of environmental factors associated with visceral leishmaniasis in northeastern Brazil, 2007-2022.Scientific reports · 2025Article
- Spatiotemporal expansion of dengue in Brazilian Amazon between 2001 and 2021.Scientific reports · 2025Article
- Temporal and spatial analysis of visceral leishmaniasis in Brazil, by age group and sex: an ecological study, 2013-2022.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025Article
- Spatial Analysis and Socio-Environmental Determinants of Canine Visceral Leishmaniasis in an Urban Area in Northeastern Brazil.Tropical medicine and infectious disease · 2024Article
- Spatiotemporal relationship between agriculture, livestock, deforestation, and visceral leishmaniasis in Brazilian legal Amazon.Scientific reports · 2024Article
- Impact of the COVID-19 Pandemic Surveillance of Visceral Leishmaniasis in Brazil: An Ecological Study.Infectious disease reports · 2024Article
- Reduced HIV/AIDS diagnosis rates and increased AIDS mortality due to late diagnosis in Brazil during the COVID-19 pandemic.Scientific reports · 2023Article
- Socio-geographical factors and vulnerability to leptospirosis in South Brazil.BMC public health · 2023Article
- Hierarchical spatiotemporal modeling of human visceral leishmaniasis in Rio Grande do Norte, Brazil.PLoS neglected tropical diseases · 2023Article
- [Spatial-temporal distribution of visceral leishmaniasis in Brazil from 2007 to 2020Distribución espaciotemporal de la leishmaniasis visceral en Brasil en el período 2007-2020].Revista panamericana de salud publica = Pan American journal of public health · 2023Article
- Article
- Spatial Heterogeneity and Its Influencing Factors of Syphilis in Ningxia, Northwest China, from 2004 to 2017: A Spatial Analysis.International journal of environmental research and public health · 2022Article
- Impact of the COVID-19 pandemic on the diagnosis of leprosy in Brazil: An ecological and population-based study.Lancet regional health. Americas · 2022Article
- Magnitude of visceral leishmaniasis and HIV coinfection and association with social determinants of health in the Northeast region of Brazil: a retrospective, spatiotemporal model (2010-2018).Parasitology research · 2022Article
- Impact of the COVID-19 Pandemic on the Diagnosis of Tuberculosis in Brazil: Is the WHO End TB Strategy at Risk?Frontiers in pharmacology · 2022Article
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundDespite visceral leishmaniasis (VL) being epidemic in most Brazilian regions, the Northeast region is responsible for the highest morbidity and mortality outcomes within the country.
objectiveTo analyse the spatiotemporal dynamics of VL cases to identify the temporal trends and high-risk areas for VL transmission, as well as the association of the disease with social vulnerability in Brazilian Northeast.
methodsWe carried out an ecological time series study employing spatial analysis techniques using all VL confirmed cases of 1,794 municipalities of Brazilian Northeast between the years 2000 to 2017. The Social Vulnerability Index (SVI) was used to represent the social vulnerability. Incidence rates were standardized and smoothed by the Local Empirical Bayesian Method. Time trends were examined through segmented linear regression. Spatiotemporal analysis consisted of uni- and bivariate Global and Local Moran indexes and space-time scan statistics.
resultsIncidence rate remained stable and ranged from 4.84 to 3.52 cases/100,000 inhabitants. There was higher case prevalence between males (62.71%), children and adolescents (63.27%), non-white (69.75%) and urban residents (62.58%). Increasing trends of new cases were observed among adult male subjects (≥ 40 years old) and urban residents. Importantly, VL incidence showed a direct spatial dependence. Spatial and space-time clusters were identified in sertão and meio-norte sub-regions, overlapping with high social vulnerability areas.
conclusionsVL is a persistent health issue in Brazilian Northeast and associated with social vulnerability. Space-time clustering of VL cases in socially vulnerable municipalities demands intersectoral public policies of surveillance and control, with focus on reducing inequalities and improving living conditions for regional inhabitants.
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