ArticlePloS one2021
Coffee consumption and risk of breast cancer: A Mendelian randomization study.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Risk of remnant cholesterol and chronic obstructive pulmonary disease: a mendelian randomization study.Journal of thoracic disease · 2025Article
- Association between DHA and depression: results from the NHANES 2011-2014 and a bidirectional Mendelian randomization analysis.European journal of medical research · 2025Article
- Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms.GeroScience · 2025Review
- Exploring the silent connection: unveiling the intricate relationship between gastroesophageal reflux disease and sleep apnea syndrome.Human genomics · 2025Article
- Bidirectional Mendelian randomization reveals causal immune cell phenotypes in rheumatoid arthritis.Medicine · 2025Article
- Negative causal exploration of systemic sclerosis: a Mendelian randomization analysis.Scientific reports · 2024Article
- Causal relationship between Alzheimer's disease and unstable angina: a bidirectional Mendelian randomization analysis.Frontiers in psychiatry · 2024Article
- Causal Relationship between Immune Cells and Gynecological Cancers through Bidirectional and Multivariable Mendelian Randomization Analyses.Journal of Cancer · 2024Article
- Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation.Journal of inflammation research · 2024Review
- Genetic associations between ULK3 and epilepsy: a two-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis.Frontiers in cardiovascular medicine · 2024Article
- A Mendelian randomization-based approach to explore the relationship between leukocyte counts and breast cancer risk in European ethnic groups.Scientific reports · 2023Article
- The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study.BMC pulmonary medicine · 2023Article
- In Vitro Bioaccessibility and Antioxidant Activity of Phenolic Compounds in Coffee-Fortified Yogurt.Molecules (Basel, Switzerland) · 2022Article
- ExPRSweb: An online repository with polygenic risk scores for common health-related exposures.American journal of human genetics · 2022Article
- Coffee consumption and cancer risk: a Mendelian randomisation study.Clinical nutrition (Edinburgh, Scotland) · 2022Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundObservational studies have reported either null or weak protective associations for coffee consumption and risk of breast cancer.
methodsWe conducted a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between coffee consumption and breast cancer risk using 33 single-nucleotide polymorphisms (SNPs) associated with coffee consumption from a genome-wide association (GWA) study on 212,119 female UK Biobank participants of White British ancestry. Risk estimates for breast cancer were retrieved from publicly available GWA summary statistics from the Breast Cancer Association Consortium (BCAC) on 122,977 cases (of which 69,501 were estrogen receptor (ER)-positive, 21,468 ER-negative) and 105,974 controls of European ancestry. Random-effects inverse variance weighted (IVW) MR analyses were performed along with several sensitivity analyses to assess the impact of potential MR assumption violations.
resultsOne cup per day increase in genetically predicted coffee consumption in women was not associated with risk of total (IVW random-effects; odds ratio (OR): 0.91, 95% confidence intervals (CI): 0.80-1.02, P: 0.12, P for instrument heterogeneity: 7.17e-13), ER-positive (OR = 0.90, 95% CI: 0.79-1.02, P: 0.09) and ER-negative breast cancer (OR: 0.88, 95% CI: 0.75-1.03, P: 0.12). Null associations were also found in the sensitivity analyses using MR-Egger (total breast cancer; OR: 1.00, 95% CI: 0.80-1.25), weighted median (OR: 0.97, 95% CI: 0.89-1.05) and weighted mode (OR: 1.00, CI: 0.93-1.07).
conclusionsThe results of this large MR study do not support an association of genetically predicted coffee consumption on breast cancer risk, but we cannot rule out existence of a weak association.
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