ArticlePLoS computational biology2021
Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Machine Learning of Personal Repertoires From Public T Cell Receptors.Immunological reviews · 2026Review
- Breast cancer is detectable from peripheral blood using machine learning over T cell receptor repertoires.NPJ systems biology and applications · 2025Article
- Nodal Expansion, Tumor Infiltration and Exhaustion of Neoepitope-Specific Th Cells After Prophylactic Peptide Vaccination and Anti-CTLA4 Therapy in Mouse Melanoma B16.International journal of molecular sciences · 2025Article
- The intratumoral landscape of T cell receptor repertoire in esophageal squamous cell carcinoma.Journal of translational medicine · 2024Article
- An unbiased comparison of immunoglobulin sequence aligners.Briefings in bioinformatics · 2024Article
- Local Enrichment with Convergence of Enriched T-Cell Clones Are Hallmarks of Effective Peptide Vaccination against B16 Melanoma.Vaccines · 2024Article
- Ovarian cancer is detectable from peripheral blood using machine learning over T-cell receptor repertoires.Briefings in bioinformatics · 2024Article
- Viral infection reveals hidden sharing of TCR CDR3 sequences between individuals.Frontiers in immunology · 2023Article
- Immune repertoire and responses to neoadjuvant TCHP therapy in HER2-positive breast cancer.Therapeutic advances in medical oncology · 2023Article
- Analysis of tumor infiltrating CD4+ and CD8+ CDR3 sequences reveals shared features putatively associated to the anti-tumor immune response.Frontiers in immunology · 2023Article
- The HLA class I immunopeptidomes of AAV capsid proteins.Frontiers in immunology · 2023Article
- Editorial: A new perspective of human CD8+ T cells with respect to their biology, protective and pathogenic role in anti-viral and tumor responses.Frontiers in immunology · 2023Article
- Counting is almost all you need.Frontiers in immunology · 2022Article
- Two Step Selection for Bias inFrontiers in immunology · 2022Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells. Here we focused on T-cell receptor (TCR) repertoires associated with spontaneous breast cancer. We studied the alpha and beta chain CDR3 domains of TCR repertoires of CD4 T cells using deep sequencing of cell populations in mice and applied the results to published TCR sequence data obtained from human patients. We screened peripheral blood T cells obtained monthly from individual mice spontaneously developing breast tumors by 5 months. We then looked at identical TCR sequences in published human studies; we used TCGA data from tumors and healthy tissues of 1,256 breast cancer resections and from 4 focused studies including sequences from tumors, lymph nodes, blood and healthy tissues, and from single cell dataset of 3 breast cancer subjects. We now report that mice spontaneously developing breast cancer manifest shared, Public CDR3 regions in both their alpha and beta and that a significant number of women with early breast cancer manifest identical CDR3 sequences. These findings suggest that the development of breast cancer is associated, across species, with biomarker, exclusive TCR repertoires.
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