Evidence map›Paper›PMID 33465049›Full record

ArticleAging2021

SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells.

Zhen-Hua Gong, Jiang Ji, Jian Yao, Jian-Feng Ji, Yasu Jiang, Gang Gao, Zhou Feng

Open access · greenAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Microrna Expression inMicroRNA (Shariqah, United Arab Emirates) · 2026
    Article
  2. [Predictive Value of A miRNA Signature for Distant Metastasis in Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhen-Hua GongDepartment of Plastic and Burn Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China.
Jiang JiDepartment of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Jian YaoDepartment of Plastic and Burn Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China.
Jian-Feng JiDepartment of Plastic and Burn Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China.
Yasu JiangDepartment of Plastic and Burn Surgery, The Second Affiliated Hospital of Nantong University, Nantong, China.
Gang GaoENT Department, The Second Affiliated Hospital of Nantong University, Nantong, China.
Zhou FengClinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong, China.
Second Affiliated Hospital of Nantong UniversityAffiliated Hospital of Nantong University · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosine kinase 1 (SphK1) is overexpressed in skin squamous cell carcinoma (SCC). It has emerged as a novel therapeutic oncotarget. The current study identified a novel SphK1-targeting microRNA, microRNA-6784 (miR-6784). Here, we show that miR-6784 is located at the cytoplasm of A431 skin SCC cells. It directly binds to

Indexed as

MicroRNAsApoptosisCarcinoma, Squamous CellCell Line, TumorCell SurvivalHumansPhosphotransferases (Alcohol Group Acceptor)Skin NeoplasmsSphingosine KinaseMicroRNAsPhosphotransferases (Alcohol Group Acceptor)Sphingosine KinasemiR-6784skin squamous cell carcinomaSphK1

Identifiers

PMID33465049
PMCPMC7906188
OpenAlexW3126114461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.