Evidence map›Paper›PMID 33464953›Full record

ArticleCirculation. Heart failure2021

Impairments in Blood Pressure Regulation and Cardiac Baroreceptor Sensitivity Among Patients With Heart Failure Supported With Continuous-Flow Left Ventricular Assist Devices.

Christine Sailer, Hannah Edelmann, Cullen Buchanan, Pedro Giro, Matthew Babcock, Christine Swanson, Melanie Spotts, Margaret Schulte, Ashley Pratt-Cordova, Greg Coe and 9 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03078972 (Effective Mechanical Circulatory Support on Exercise Capacity in Heart Failure), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03078972 unknown statusnot on this map

Effective Mechanical Circulatory Support on Exercise Capacity in Heart Failure

TypeobservationalSponsorUniversity of Colorado, DenverRan2017 to 2023Enrolled60ConditionsHeart Failure，Congestive
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Christine SailerDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Hannah EdelmannUniversity of Colorado-Denver (H.E.).
Cullen BuchananDepartment of Medicine (C.B., P.G.), University of Colorado Anschutz Medical Campus, Aurora.
Pedro GiroDepartment of Medicine (C.B., P.G.), University of Colorado Anschutz Medical Campus, Aurora.
Matthew BabcockDivision of Geriatric Medicine, Department of Medicine (M.B., W.K.), University of Colorado Anschutz Medical Campus, Aurora.
Christine SwansonDepartment of Medicine-Endocrinology, Metabolism and Diabetes (C.S.), University of Colorado Anschutz Medical Campus, Aurora.
Melanie SpottsClinical and Translational Research Center (M. Spotts, M. Schulte, A.P.-C., W.K., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Margaret SchulteClinical and Translational Research Center (M. Spotts, M. Schulte, A.P.-C., W.K., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Ashley Pratt-CordovaClinical and Translational Research Center (M. Spotts, M. Schulte, A.P.-C., W.K., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Greg CoeDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Mark BeindorffDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Robert L PageDepartment of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Services, Aurora (R.L.P.).
Amrut V AmbardekarDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Jay D PalDepartment of Cardiothoracic Surgery (J.D.P.), University of Colorado Anschutz Medical Campus, Aurora.
Wendy KohrtDivision of Geriatric Medicine, Department of Medicine (M.B., W.K.), University of Colorado Anschutz Medical Campus, Aurora.
Eugene WolfelDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
Justin S LawleyDepartment of Sport Science, University of Innsbruck, Austria (J.S.L.).
Takashi TarumiHuman Informatics Interaction Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki prefecture, Japan (T.T.).
William K CornwellDepartment of Medicine-Cardiology (C.S., G.C., M.B., A.V.A., E.W., W.K.C.), University of Colorado Anschutz Medical Campus, Aurora.
University of Colorado Anschutz Medical Campus · USHuman Computer Interaction (Switzerland) · CHUniversität Innsbruck · ATUniversity of Denver · USUniversity of Montana · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Effect of Mechanical Circulatory Support on Exercise Capacity in Heart FailureK23HL132048 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI CORNWELL, WILLIAM · 2016 to 2020
$819k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS K23 HL132048
6 · The paper itself

Abstract

backgroundContinuous-flow (CF) left ventricular assist devices (LVADs) improve outcomes for patients with advanced heart failure (HF). However, the lack of a physiological pulse predisposes to side-effects including uncontrolled blood pressure (BP), and there are little data regarding the impact of CF-LVADs on BP regulation.

methodsTwelve patients (10 males, 60±11 years) with advanced heart failure completed hemodynamic assessment 2.7±4.1 months before, and 4.3±1.3 months following CF-LVAD implantation. Heart rate and systolic BP via arterial catheterization were monitored during Valsalva maneuver, spontaneous breathing, and a 0.05 Hz repetitive squat-stand maneuver to characterize cardiac baroreceptor sensitivity. Plasma norepinephrine levels were assessed during head-up tilt at supine, 30

resultsCardiac baroreceptor sensitivity, determined by Valsalva as well as Fourier transformation and transfer function gain of Heart rate and systolic BP during spontaneous breathing and squat-stand maneuver, was impaired before and following LVAD implantation. Norepinephrine levels were markedly elevated pre-LVAD and improved-but remained elevated post-LVAD (supine norepinephrine pre-LVAD versus post-LVAD: 654±437 versus 323±164 pg/mL). BP increased during cardiopulmonary exercise testing post-LVAD, but the magnitude of change was modest and comparable to the changes observed during the pre-LVAD cardiopulmonary exercise testing.

conclusionsAmong patients with advanced heart failure with reduced ejection fraction, CF-LVAD implantation is associated with modest improvements in autonomic tone, but persistent reductions in cardiac baroreceptor sensitivity. Exercise-induced increases in BP are blunted. These findings shed new light on mechanisms for adverse events such as stroke, and persistent reductions in functional capacity, among patients supported by CF-LVADs. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03078972.

Indexed as

Heart-Assist DevicesAgedBaroreflexBlood PressureExercise TestFemaleHeart FailureHeart RateHemodynamicsHumansMaleMiddle AgedNorepinephrinePressoreceptorsValsalva ManeuverNorepinephrinearterial pressureblood pressureheart failureheart ratehypertension

Identifiers

PMID33464953
PMCPMC7818348
OpenAlexW3123035356

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.