Evidence map›Paper›PMID 33464826›Full record

ArticleBiochemistry2021

Orthogonal Control of DNA Nanoswitches with Mixed Physical and Biochemical Cues.

Nathan T Forrest, Javier Vilcapoma, Kristina Alejos, Ken Halvorsen, Arun Richard Chandrasekaran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Light-responsive DNA nanostructures.Nature reviews. Chemistry · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathan T ForrestThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.
Javier VilcapomaThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.
Kristina AlejosThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID 0000-0002-2578-1339
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID 0000-0001-6757-5464

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
NIGMS NIH HHS R35 GM124720
6 · The paper itself

Abstract

Nanoscale devices that can respond to external stimuli have potential applications in drug delivery, biosensing, and molecular computation. Construction using DNA has provided many such devices that can respond to cues such as nucleic acids, proteins, pH, light, or temperature. However, simultaneous control of molecular devices is still limited. Here, we present orthogonal control of DNA nanoswitches using physical (light) and biochemical (enzyme and nucleic acid) triggers. Each one of these triggers controls the reconfiguration of specific nanoswitches from locked to open states within a mixture and can be used in parallel to control a combination of nanoswitches. Such dynamic control over nanoscale devices allows the incorporation of tunable portions within larger structures as well as spatiotemporal control of DNA nanostructures.

Indexed as

Nucleic Acid ConformationDNANanostructuresDNA

Identifiers

PMID33464826
PMCPMC8034807

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.