Evidence map›Paper›PMID 33464700›Full record

ArticleThe Kaohsiung journal of medical sciences2021

Herp knockout protects against nonalcoholic fatty liver disease in mice on a high fat diet.

Zhi-Xiong Lei, Juan-Juan Wang, Kang Li, Ping Liu

Open access · goldAbstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhi-Xiong LeiDepartment of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Juan-Juan WangDepartment of Endocrinology, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Kang LiDepartment of Cardiothoracic Surgery, Affiliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, P.R. China.
Ping LiuDepartment of Infectious Diseases, Renmin Hospital, Hubei University of Medicine, Shiyan, P.R. China.ORCID https://orcid.org/0000-0003-3711-7694
Hubei University of Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to discover the role of Homocysteine-induced ER protein (Herp) deficiency in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD). After 8 weeks of feeding with normal-fat diet (NFD) or HFD, WT (wild type) and Herp

Indexed as

Diet, High-FatActivating Transcription Factor 4AnimalsApoptosisBody WeightEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressFibrosisHepatocytesHomocysteineLiverMembrane ProteinsMiceMice, TransgenicNon-alcoholic Fatty Liver DiseaseOrgan SizeActivating Transcription Factor 4Atf4 protein, mouseDdit3 protein, mouseEndoplasmic Reticulum Chaperone BiPHerpud1 protein, mouseHomocysteineHspa5 protein, mouseMembrane ProteinsTranscription Factor CHOPgene knockoutHerphigh-fat dietNAFLD

Identifiers

PMID33464700
PMCPMC11896413
OpenAlexW3122651009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.