ArticleEpilepsia2021
Predicting mood decline following temporal lobe epilepsy surgery in adults.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
- Healthcare professionals' knowledge, attitude, and perception of epilepsy surgery: A systematic review.Epilepsy & behavior : E&B · 2021Pooled it
- Prepare, don't scare: Rethinking cognitive readiness before epilepsy surgery.Epilepsia open · 2026Article
- Article
- Multimodal artificial intelligence in epilepsy: antiseizure medication response, epileptogenic zone localization, and surgical outcome prediction.Frontiers in neurology · 2026Review
- Surgical decision making in the era of supramarginal glioma resections: a current perspective and narrative review.CNS oncology · 2025Review
- Seminars in epileptology: Presurgical epilepsy evaluation.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- Conducting Performance-Assisted Resections in the Right Temporo-Insular Cortex: A Real-Time Neuropsychological Testing (RTNT) Protocol.Brain sciences · 2025Article
- Psychopathology in children before and after epilepsy surgery: a prospective controlled study.Epilepsia · 2025Article
- Epilepsy Therapies Symposium | Do We Really "Outgrow" Seizures?Epilepsy currents · 2024Review
- Unveiling the interoception impairment in various major depressive disorder stages.CNS neuroscience & therapeutics · 2024Article
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Early Identification of Candidates for Epilepsy Surgery: A Multicenter, Machine Learning, Prospective Validation Study.Neurology · 2024Article
- Expert opinion on diagnosis and management of epilepsy-associated comorbidities.Epilepsia open · 2024Review
- The relationship between mood and anxiety and cognitive phenotypes in adults with pharmacoresistant temporal lobe epilepsy.Epilepsia · 2023Observational
- Characterization and Prediction of Short-term Outcomes in Memory After Temporal Lobe Resection in Children With Epilepsy.Neurology · 2023Article
- Bringing Statistics to the Clinic to Predict the Future: Nomograms for Psychiatric Outcomes of Epilepsy Surgery.Epilepsy currents · 2021Article
- Automated Identification of Surgical Candidates and Estimation of Postoperative Seizure Freedom in Children - A Focused Review.Seminars in pediatric neurology · 2021Review
- Improving the prediction of epilepsy surgery outcomes using basic scalp EEG findings.Epilepsia · 2021Article
- Response: Predicting mood decline following temporal lobe epilepsy surgery in adults.Epilepsia · 2021Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo develop a model to predict the probability of mood decline in adults following temporal lobe resection for the treatment of pharmacoresistant epilepsy.
methodsVariable selection was performed on 492 patients from the Cleveland Clinic using best subsets regression. After completing variable selection, a subset of variables was requested from four epilepsy surgery centers across North America (n = 100). All data were combined to develop a final model to predict postoperative mood decline (N = 592). Internal validation with bootstrap resampling was performed. A clinically significant increase in depressive symptoms was defined as a 15% increase in Beck Depression Inventory-Second Edition score and a postoperative raw score > 11.
resultsFourteen percent of patients in the Cleveland Clinic cohort and 22% of patients in the external cohort experienced clinically significant increases in depressive symptoms following surgery. The final prediction model included six predictor variables: psychiatric history, resection side, relationship status, verbal fluency score, age at preoperative testing, and presence/absence of malformation of cortical development on magnetic resonance imaging. The model had an optimism-adjusted c-statistic of .70 and good calibration, with slight probability overestimation in higher risk patients. SIGNIFICANCE: Clinicians can utilize our nomogram via a paper tool or online calculator to estimate the risk of postoperative mood decline for individual patients prior to temporal lobe epilepsy surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.