Evidence map›Paper›PMID 33464363›Full record

ArticleEuropean journal of nutrition2021

Relevance of fructose intake in adolescence for fatty liver indices in young adulthood.

Ines Perrar, Anette E Buyken, Katharina J Penczynski, Thomas Remer, Gunter G Kuhnle, Christian Herder, Michael Roden, Karen Della Corte, Ute Nöthlings, Ute Alexy

Open access · hybridAbstract read
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Dietary Fructose and Fructose-Induced Pathologies.Annual review of nutrition · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Ines PerrarInstitute of Nutritional and Food Sciences , Nutritional Epidemiology, University of Bonn, DONALD Study, Heinstück 11, 44225, Dortmund, Germany.
Anette E BuykenInstitute of Nutrition, Consumption and Health, Faculty of Natural Sciences, University Paderborn, Warburger Straße 100, 33098, Paderborn, Germany.
Katharina J PenczynskiInstitute of Nutritional and Food Sciences , Nutritional Epidemiology, University of Bonn, DONALD Study, Heinstück 11, 44225, Dortmund, Germany.
Thomas RemerInstitute of Nutritional and Food Sciences , Nutritional Epidemiology, University of Bonn, DONALD Study, Heinstück 11, 44225, Dortmund, Germany.
Gunter G KuhnleDepartment of Food and Nutritional Sciences, University of Reading, Whiteknights, RG6 6UR, UK.
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Karen Della CorteInstitute of Nutrition, Consumption and Health, Faculty of Natural Sciences, University Paderborn, Warburger Straße 100, 33098, Paderborn, Germany.
Ute NöthlingsInstitute of Nutritional and Food Sciences , Nutritional Epidemiology, University of Bonn, DONALD Study, Heinstück 11, 44225, Dortmund, Germany.
Ute AlexyInstitute of Nutritional and Food Sciences , Nutritional Epidemiology, University of Bonn, DONALD Study, Heinstück 11, 44225, Dortmund, Germany. alexy@uni-bonn.de.ORCID http://orcid.org/0000-0002-1488-5175
University of Bonn · DEDeutsches Diabetes-Zentrum e.V. · DEPaderborn University · DEUniversity of Reading · GB

Funding

Bundesanstalt für Landwirtschaft und Ernährung 2816HS024
6 · The paper itself

Abstract

purposeTo examine the association between fructose intake in adolescence and fatty liver indices (hepatic steatosis index (HSI), fatty liver index (FLI)) in young adulthood.

methodsOverall, 246 participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study who had a fasting blood sample in adulthood (18-36 years), at least two 3-day weighed dietary records for calculating fructose intakes and other fructose-containing sugars (total (TS), free (FS), added sugar (AS)) as well as two complete 24-h urine samples for calculating sugar excretion (fructose excretion (FE), fructose + sucrose excretion (FE + SE)) in adolescence (males: 9.5-16.5 years; females: 8.5-15.5 years) were analysed using multivariable linear regression analyses.

resultsOn the level of dietary intake, no prospective associations were observed between adolescent fructose intake and both adult fatty liver indices, whereas higher FS intakes were associated with lower levels of HSI (P

conclusionThe present study does not provide unambiguous support for a detrimental impact of adolescent fructose intake on adult liver health. Nonetheless, further examinations estimating exposure by means of urinary excretion as well as dietary intake levels appear warranted.

Indexed as

Fatty LiverFructoseAdolescentAdultDiet RecordsFemaleHumansMaleSucroseYoung AdultFructoseSucroseAdolescenceBiomarkerFructoseNon-alcoholic fatty liver diseaseSugar intakeYoung adulthood

Identifiers

PMID33464363
PMCPMC8354997
OpenAlexW3121870292

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.