ArticleeLife2021
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.
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In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
–field-weighted citation impact
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Who cites it
58 citing papers in PubMed.
- Pervasive weak incompatibilities shape phenotypic variation and genome evolution in yeast hybrids.Nature communications · 2026Article
- Toward a Functional Genetics of Adaptation: Insights From Microbial Experimental Evolution.Genome biology and evolution · 2026Review
- The evolution of azole resistance through a reduced spore dormancy pathway associated with loss of SUMOylation function inApplied and environmental microbiology · 2026Article
- Pseudogene revival drives repeated adaptation in fission yeast.Molecular biology and evolution · 2026Article
- Sex decreases the pleiotropic costs of local adaptation by purging hitchhiking load.Science (New York, N.Y.) · 2026Article
- Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution.Nature ecology & evolution · 2026Article
- Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Rapid adaptation and extinction in synchronized outdoor evolution experiments ofScience (New York, N.Y.) · 2026Article
- Experimental Evolution of Yeast Reveals Trade-offs Between Early and Late Stationary Phase.bioRxiv : the preprint server for biology · 2026Article
- Studying adaptation at the invisible scale.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Wanted: A population genetic theory of biological noise regulation.PLoS genetics · 2026Article
- Estimating the distribution of fitness effects of loss of heterozygosity (LOH) events using an engineered library of Saccharomyces cerevisiae.PLoS genetics · 2026Article
- Comparative Mitogenomics Reveals Intron Dynamics and Mitochondrial Gene Expression Shifts in Domesticated and WildJournal of fungi (Basel, Switzerland) · 2026Article
- Weak pervasive incompatibilities and compensatory adaptation drive hybrid genome evolution in yeast.bioRxiv : the preprint server for biology · 2026Article
- Experimental evolution in an era of molecular manipulation.Nature reviews. Genetics · 2026Review
- Protein structure shapes natural genetic variation andbioRxiv : the preprint server for biology · 2025Article
- Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution.Nature ecology & evolution · 2025Article
- Limited population structure but signals of recent selection in introduced African Fig Fly (Zaprionus indianus) in North America.G3 (Bethesda, Md.) · 2025Article
- Refining the resolution of the yeast genotype-phenotype map using single-cell RNA-sequencing.eLife · 2025Article
- Fusion of microscopic and diffraction images with VGG net for budding yeast recognition in imaging flow cytometry.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Milo S JohnsonDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-0169-2494
Shreyas GopalakrishnanDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0002-7243-0005
Juhee GoyalDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Megan E DillinghamQuantitative Biology Initiative, Harvard University, Cambridge, United States.
Christopher W BakerleeDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Parris T HumphreyDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Tanush JagdishDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Elizabeth R JerisonDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0003-3793-8839
Katya KoshelevaDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Katherine R LawrenceDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Jiseon MinDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Alief MoulanaDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Angela M PhillipsDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Julia C PiperDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Ramya PurkantiDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Artur Rego-CostaDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Michael J McDonaldDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Alex N Nguyen BaDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.
Michael M DesaiDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, United States.ORCID 0000-0002-9581-1150
Funding
Microbial Adaptation and the Statistics of Epistasis and PleiotropyR01GM104239 · NIGMS · HARVARD UNIVERSITY · PI DESAI, MICHAEL M · 2013 to 2025
$4.5MNIGMS NIH HHS R01 GM104239
Abstract
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205
Indexed as
Adaptation, BiologicalEvolution, MolecularMutationPhenotypeDiploidyMutation RateSaccharomyces cerevisiaedynamics of adaptationevolutionary biologyexperimental evolutionS. cerevisiaeyeast
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.