ArticleJournal of feline medicine and surgery2021
Incidence of microcytosis in hyperthyroid cats referred for radioiodine treatment.
Article in Journal of feline medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Haematological Tracking of Thyroid Status During Methimazole Therapy and After Treatment Interruption in Hyperthyroid Cats: A Prospective Longitudinal Cohort Study.Veterinary sciences · 2026Article
- Changes in Erythrocytes in 88 Hyperthyroid Cats.Animals : an open access journal from MDPI · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study aimed to document the incidence of erythrocyte microcytosis in a population of hyperthyroid cats referred for radioiodine (RAI) treatment. Microcytosis has been observed but not described in feline hyperthyroid patients and is associated with hyperthyroidism in humans.
methodsRetrospective clinicopathological data were collected for cats undergoing RAI between January and December 2017. Microcytosis was defined as mean cell volume (MCV) <41.3 fl using the ADVIA 2120 haematology analyser (Siemens) and identified on blood smear examination by a haematology laboratory scientist or board-certified specialist in veterinary clinical pathology. Hyperthyroidism was classified as mild (total thyroxine [TT4] 60-124.9 nmol/l), moderate (TT4 125-250 nmol/l) or severe (TT4 ⩾251 nmol/l) immediately before RAI. Data were analysed descriptively and using a Pearson correlation coefficient to test the relationship between TT4 and microcytosis, and time elapsed between first diagnosis and MCV.
resultsThere were 41 female and 37 male cats with an age range of 7.2-20.8 years. Most cats were non-pedigree (98.7%). Microcytosis (median MCV 39.8 fl, interquartile range 32.3-41.2) was present in 29.5% (23/78) of the cats. Of the 23 microcytic samples, 86.9% (20/23) were confirmed as such on smear examination. Of mildly, moderately and severely hyperthyroid cats, 23% (6/26), 28.1% (9/32) and 40% (8/20) were microcytic, respectively. Two microcytic cats had low red blood cell counts (<6 × 10 CONCLUSIONS AND RELEVANCE: Microcytosis was present in a significant proportion of hyperthyroid cats, most without clinically significant comorbidities, and resolved in some following RAI.
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