ArticlePhysiological reports2021
Physical activity differentially regulates VEGF, PlGF, and their receptors in the human placenta.
Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Maternal exercise alters placental proteome in an exercise mode-specific manner.American journal of physiology. Endocrinology and metabolism · 2025Trial
- Maternal Exercise and Nutrition Function as Interconnected Regulators of Embryonic Organogenesis and Fetal Development.Nutrients · 2026Review
- Article
- Placental Pathology and Placental Growth Factor (PlGF)/Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Pathway Expression Evaluation in Fetal Congenital Heart Defects.Life (Basel, Switzerland) · 2025Article
- Association of physical activity during pregnancy with labor and delivery in nulliparous patients.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Role of vitamin D in the pathogenesis of early-onset preeclampsia: a narrative review.Frontiers in nutrition · 2025Review
- Up-regulated mRNA expression of VEGFA receptors (FLT1 and KDR) in placentas after assisted reproductive technology fertilization.Journal of applied genetics · 2024Article
- Physical Activity during Pregnancy and Risk of Gestational Diabetes Mellitus: A Meta-Review.Life (Basel, Switzerland) · 2024Review
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Placental structural adaptation to maternal physical activity and sedentary behavior: findings of the DALI lifestyle study.Human reproduction (Oxford, England) · 2024Article
- Combination of Atractylenolide I, Atractylenolide III, and Paeoniflorin promotes angiogenesis and improves neurological recovery in a mouse model of ischemic Stroke.Chinese medicine · 2024Article
- The role of physical activity in the physiological activation of the scholastic pre-requirements.AIMS neuroscience · 2024Article
- Assessing lipoxin-mediated inflammatory responses in the second trimester of pregnancy among women with obesity: A comprehensive analysis.Turkish journal of obstetrics and gynecology · 2023Article
- Maternal physical activity affects yolk sac size and growth in early pregnancy, but girls and boys use different strategies.Scientific reports · 2023Article
- Maternal Exercise Prior to and during Gestation Induces Sex-Specific Alterations in the Mouse Placenta.International journal of molecular sciences · 2023Article
- Examining the Effects of Gestational Physical Activity and Hofbauer Cell Polarization on Angiogenic Factors.International journal of environmental research and public health · 2023Article
- Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals.Physiological reports · 2023Article
- The Influence of Exercise-Associated Small Extracellular Vesicles on TrophoblastsBiomedicines · 2023Article
- Preeclampsia and Obesity-The Preventive Role of Exercise.International journal of environmental research and public health · 2023Review
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Physical activity (PA) has beneficial effects on the function of many organs by modulating their vascular development. Regular PA during pregnancy is associated with favorable short- and long-term outcomes for both mother and fetus. During pregnancy, appropriate vascularization of the placenta is crucial for adequate maternal-fetal nutrient and gas exchange. How PA modulates angiogenic factors, VEGF, and its receptors in the human placenta, is as of yet, unknown. We objectively measured the PA of women at 24-28 and 34-38 weeks of gestation. Participants were considered "active" if they had met or exceeded 150 min of moderate-intensity PA per week during their 2nd trimester. Term placenta tissues were collected from active (n = 23) or inactive (n = 22) women immediately after delivery. We examined the expression of the angiogenic factors VEGF, PlGF, VEGFR-1, and VEGFR-2 in the placenta. Western blot analysis showed VEGF and its receptor, VEGFR-1 was significantly (p < 0.05) higher both at the protein and mRNA levels in placenta from physically active compared to inactive women. No difference in VEGFR-2 was observed. Furthermore, immunohistochemistry showed differential staining patterns of VEGF and its receptors in placental endothelial, stromal, and trophoblast cells and in the syncytial brush border. In comparison, PlGF expression did not differ either at the protein or mRNA level in the placenta from physically active or inactive women. The expression and localization pattern of VEGF and its receptors suggest that PA during pregnancy may support a pro-angiogenic milieu to the placental vascular network.
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