Evidence map›Paper›PMID 33463770›Full record

ArticleJournal of veterinary internal medicine2020

Outcome and treatments of dogs with aortic thrombosis: 100 cases (1997-2014).

Mackenzie Ruehl, Alex M Lynch, Therese E O'Toole, Bari Morris, John Rush, C Guillermo Couto, Samantha Hmelo, Stacey Sonnenshein, Amy Butler, Julien Guillaumin

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Coagulation status of immune-mediated polyarthritis in dogs.The Journal of small animal practice · 2025
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  6. Basic triage in dogs and cats: Part III.The Canadian veterinary journal = La revue veterinaire canadienne · 2024
    Review
  7. Rapport de cas Surgical retrieval of a migrated vascular access port catheter in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2023
    Article
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  11. Article
  12. Article
  13. Article
  14. Monitoring of Rivaroxaban Therapy in Hypercoagulable Dogs.Journal of veterinary internal medicine
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Mackenzie RuehlMedVet Hilliard, Hilliard, Ohio, USA.ORCID https://orcid.org/0000-0001-7117-1737
Alex M LynchDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0002-8747-094X
Therese E O'TooleDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.
Bari MorrisVCA Shoreline Veterinary Referral and Emergency Center, Shelton, Connecticut, USA.
John RushDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8277-8996
C Guillermo CoutoCouto Veterinary Consultants, Hilliard, Ohio, USA.
Samantha HmeloUrban Animal Hospital, Seatle, Washington, USA.
Stacey SonnensheinOakVet Animal Specialty Hospital, Oakland, California, USA.
Amy ButlerCritical Consults, LLC, Pittsburgh, Pennsylvania, USA.
Julien GuillauminDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.ORCID https://orcid.org/0000-0001-8622-4387
Ohio Business College · USTufts University · USBioHybrid Solutions (United States) · USCalifornia Animal Hospital · USColorado State University · USNorth Carolina State University · USShoreline Community College · USUrbana University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic thrombosis (ATh) is an uncommon condition in dogs, with limited understanding of risks factors, outcomes, and treatments. OBJECTIVES/HYPOTHESIS: To describe potential risk factors, outcome, and treatments in dogs with ATh. ANIMALS: Client-owned dogs with a diagnosis of ATh based on ultrasonographic or gross necropsy examination.

methodMulticentric retrospective study from 2 academic institutions.

resultsOne hundred dogs were identified. Anti-thrombin diagnosis, 35/100 dogs were nonambulatory. The dogs were classified as acute (n = 27), chronic (n = 72), or unknown (n = 1). Fifty-four dogs had at least one comorbidity thought to predispose to ATh, and 23 others had multiple comorbidities. The remaining 23 dogs with no obvious comorbidities were classified as cryptogenic. Concurrent illnesses potentially related to the development of ATh included protein-losing nephropathy (PLN) (n = 32), neoplasia (n = 22), exogenous corticosteroid administration (n = 16), endocrine disease (n = 13), and infection (n = 9). Dogs with PLN had lower antithrombin activity than those without PLN (64% and 82%, respectively) (P = .04). Sixty-five dogs were hospitalized with 41 subsequently discharged. Sixteen were treated as outpatient and 19 euthanized at admission. In-hospital treatments varied, but included thrombolytics (n = 12), alone or in combination with thrombectomy (n = 9). Fifty-seven dogs survived to discharge. Sixteen were alive at 180 days. Using regression analysis, ambulation status at the time of presentation was significantly correlated with survival-to-discharge (P < .001). CONCLUSIONS/CLINICAL IMPORTANCE: Dogs with ATh have a poor prognosis, with nonambulatory dogs at the time of presentation having worse outcome. Although the presence of comorbid conditions associated with hypercoagulability is common, an underlying cause for ATh was not always identified.

Indexed as

Dog DiseasesThrombosisAnimalsBlood Coagulation TestsDogsProteinuriaRetrospective Studiescanineprotein‐losing nephropathysaddle thrombusthromboembolismthrombus

Identifiers

PMID33463770
PMCPMC7517508
OpenAlexW3049301101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.