Evidence map›Paper›PMID 33463757›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020

Restriction of Dietary Phosphate Ameliorates Skeletal Abnormalities in a Mouse Model for Craniometaphyseal Dysplasia.

Yasuyuki Fujii, Eszter Kozak, Eliane Dutra, Andras Varadi, Ernst J Reichenberger, I-Ping Chen

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01630460 (Identification of Mutations That Lead to Craniometaphyseal Dysplasia in Families and Isolated Cases and Studies of Cellular and Molecular Mechanisms), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01630460 recruitingnot on this map

Identification of Mutations That Lead to Craniometaphyseal Dysplasia in Families and Isolated Cases and Studies of Cellular and Molecular Mechanisms

TypeobservationalSponsorUConn HealthRan2009 to 2030Enrolled600ConditionsCraniometaphyseal Dysplasia
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The Mineralization Regulator ANKH Mediates Cellular Efflux of ATP, Not Pyrophosphate.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yasuyuki FujiiDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Eszter KozakInstitute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences Centre of Excellence, Budapest, Hungary.
Eliane DutraDepartment of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
Andras VaradiInstitute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences Centre of Excellence, Budapest, Hungary.
Ernst J ReichenbergerDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.
I-Ping ChenDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, USA.ORCID 0000-0002-7349-3091
UConn Health · USInstitute of Molecular Life Sciences · HU

Funding

Pathogenic Mechanisms of Craniometaphyseal DysplasiaR01DE025664 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI I-Ping Chen · 2016 to 2026
$4.5M
Control of Bone Formation in Craniometaphyseal DysplasiaR01DE019458 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI REICHENBERGER, ERNST J · 2011 to 2015
$1.8M
NIDCR NIH HHS DE019458NIDCR NIH HHS DE025664NIDCR NIH HHS R01 DE019458NIDCR NIH HHS R01 DE025664
6 · The paper itself

Abstract

Craniometaphyseal dysplasia (CMD), a rare genetic bone disorder, is characterized by lifelong progressive thickening of craniofacial bones and metaphyseal flaring of long bones. The autosomal dominant form of CMD is caused by mutations in the progressive ankylosis gene ANKH (mouse ortholog Ank), encoding a pyrophosphate (PPi) transporter. We previously reported reduced formation and function of osteoblasts and osteoclasts in a knockin (KI) mouse model for CMD (Ank

Indexed as

DietAnimalsBone Diseases, DevelopmentalCraniofacial AbnormalitiesDisease Models, AnimalFemaleGene Knock-In TechniquesHumansHyperostosisHypertelorismMaleMicePhosphatesPhosphate Transport ProteinsPhosphatesPhosphate Transport ProteinsBONE HISTOMORPHOMETRYBONE QCT/μCTGENETIC ANIMAL MODELSOSTEOBLASTSOSTEOCLASTS

Identifiers

PMID33463757
PMCPMC9164311
OpenAlexW3035991773

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.