Evidence map›Paper›PMID 33463721›Full record

Observational studyJournal of medical virology2021

A U-shaped association between baseline neutrophil count and COVID-19-related mortality: A retrospective cohort study.

Wei Fu, Chi Chen, Xin-Lin Chen, Kun Wang, Peiyuan Zuo, Yuwei Liu, Meng Zhang, Xiaofang Zhao, Songpu Xie, Hao Zhang and 2 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Review
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Wei FuDepartment of Gastroenterology, 925th Hospital of PLA Joint Logistics Support Force, Guiyang, China.ORCID 0000-0001-8155-431X
Chi ChenDepartment of Immunology and Microbiology, GuiZhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Xin-Lin ChenDepartment of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
Kun WangDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
Peiyuan ZuoDepartment of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuwei LiuDepartment of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Meng ZhangDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
Xiaofang ZhaoDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
Songpu XieDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
Hao ZhangDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
Yan GengDepartment of Gastroenterology, 923th Hospital of PLA Joint Logistics Support Force, Nanning, China.
Chengyun LiuDepartment of Epidemiology and Biostatistics, Empower U, X&Y solutions Inc., Boston, USA.
303 Hospital of People's Liberation Army · CN81th Hospital of PLA · CNTongji Hospital · CNUnion Hospital · CNWuhan University · CN

Funding

National Natural Science Foundation of China 81671386National Natural Science Foundation of China 81974222Supported by Foundation of Guiyang Municipal Science and Technology Bureau [2020]No.6
6 · The paper itself

Abstract

Several descriptive studies have reported that higher neutrophil count (NC) may be correlated with poor prognosis in patients with confirmed COVID-19 infection. However, the findings from these studies are limited by methodology and data analysis. This study is a cohort study. We nonselectively and consecutively collected a total of 663 participants in a Chinese hospital from January 7 to February 28. Standardized and two-piecewise Cox regression model were employed to evaluate the association between baseline neutrophil count (bNC), neutrophil count change rate (NCR), and death. bNC had a U-shaped association with death. In the range of 0.1 to ≤1.49 × 10

Indexed as

ChinaCOVID-19FemaleHospitalizationHumansLymphocyte CountMaleMiddle AgedNeutrophilsPrognosisRetrospective StudiesRiskRisk FactorsSARS-CoV-2baseline neutrophil countchange rateCOVID-19-infectionnonlinearity

Identifiers

PMID33463721
PMCPMC8014534
OpenAlexW3122176695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.