Evidence map›Paper›PMID 33463566›Full record

ArticleIndian journal of ophthalmology2021

Mucor in a Viral Land: A Tale of Two Pathogens.

Mrittika Sen, Sumeet Lahane, Tatyarao P Lahane, Ragini Parekh, Santosh G Honavar

Open access · diamondAbstract readMulticenter Study
In one paragraph

Article in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 8 pooled it
24.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 8 syntheses or guidelines pooled it, 384 citations in OpenAlex.

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  10. Challenges and opportunities in the management of severe pneumonia. Key concepts from the Seventh Annual Meeting of Spanish Experts 2025.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Review
  11. Mucormycosis and Hearing: A Hospital-Based Study.International archives of otorhinolaryngology · 2025
    Article
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  20. Risk Factors Associated with Mortality in Patients with Mucormycosis Post Severe Acute Respiratory Syndrome Coronavirus-2 (Sars-Cov-2) Infection.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article

127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mrittika SenOphthalmic and Facial Plastic Surgery and Ocular Oncology Services, Centre for Sight, Hyderabad, India.
Sumeet LahaneDepartment of Ophthalmology, Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Tatyarao P LahaneDepartment of Ophthalmology, Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Ragini ParekhDepartment of Ophthalmology, Sir JJ Group of Hospitals, Mumbai, Maharashtra, India.
Santosh G HonavarOphthalmic and Facial Plastic Surgery and Ocular Oncology Services, Centre for Sight, Hyderabad, India.
Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals · INCentre for Sight · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: COVID-19 infection, its treatment, resultant immunosuppression, and pre-existing comorbidities have made patients vulnerable to secondary infections including mucormycosis. It is important to understand the presentation, temporal sequence, risk factors, and outcomes to undertake measures for prevention and treatment. Methods: We conducted a retrospective, interventional study on six consecutive patients with COVID-19 who developed rhino-orbital mucormycosis and were managed at two tertiary ophthalmic referral centers in India between August 1 and December 15, 2020. Diagnosis of mucormycosis was based on clinical features, culture, and histopathology from sinus biopsy. Patients were treated with intravenous liposomal amphotericin B with addition of posaconazole and surgical debridement of necrotic tissue. Results: All patients were male, mean age 60.5 ± 12 (46.2-73.9) years, type 2 diabetics with mean blood glucose level of 222.5 ± 144.4 (86-404) mg/dL. Except for one patient who was diagnosed with mucormycosis concurrently with COVID-19, all patients received systemic corticosteroids for the treatment of COVID-19. The mean duration between diagnosis of COVID-19 and development of symptoms of mucor was 15.6 ± 9.6 (3-42) days. All patients underwent endoscopic sinus debridement, whereas two patients required orbital exenteration. At the last follow-up, all six patients were alive, on antifungal therapy. Conclusion: Mucormycosis is a life-threatening, opportunistic infection, and patients with moderate to severe COVID-19 are more susceptible to it. Uncontrolled diabetes mellitus and use of corticosteroids increase the risk of invasive fungal infection with mucormycosis which can develop during the course of the illness or as a sequelae. High index of suspicion, early diagnosis, and appropriate management can improve survival.

Indexed as

PandemicsSARS-CoV-2AgedComorbidityCOVID-19Eye Infections, FungalFemaleHumansMaleMiddle AgedMucoralesMucormycosisRetrospective StudiesCorticosteroidsCOVID-19diabetes mellitusmucormycosis

Identifiers

PMID33463566
PMCPMC7933891
OpenAlexW3122442588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.