ReviewIndian journal of ophthalmology2021
Pediatric keratoconus - Current perspectives and clinical challenges.
Review in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- The candidate proteins associated with keratoconus: A meta-analysis and bioinformatic analysis.PloS one · 2024Pooled it
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- Biomechanical and Tomographic Outcomes in Pediatric Keratoconus Treated with Conventional Epithelium-Off Corneal Collagen Cross-Linking.Medicina (Kaunas, Lithuania) · 2026Observational
- Characterization of the SKC mouse strain as a potential model for keratoconus.bioRxiv : the preprint server for biology · 2026Article
- Sex hormone-mediated corneal remodeling in keratoconus: a multivariate analysis of tomographic and biomechanical variations across gender, age, and menstrual phases.BMC ophthalmology · 2026Article
- Characterisation and risk factors of astigmatism among children and adolescents aged 3-20 years in Northwestern China.Journal of global health · 2026Article
- Corneal Variables in Children: A Literature Review.Clinical optometry · 2026Review
- The effect of altitude on the incidence of keratoconus in Israel-a population-based study.Eye (London, England) · 2025Article
- Efficacy and Safety of 7.2 J/cm2 Accelerated Corneal Cross-Linking in Pediatric and Adult Keratoconus: A Comparative Study.Korean journal of ophthalmology : KJO · 2025Article
- Neural Network Prediction of Keratoconus in AIPL1-Linked Leber Congenital Amaurosis: A Proof-of-Concept Pilot Study.Journal of clinical medicine · 2025Article
- Comparison of the 1-year efficacy of epithelium-off and transepithelial accelerated corneal collagen crosslinking in adolescent keratoconus.Eye (London, England) · 2025Observational
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
- Keratoconus in children in Tunisia: Epidemiological, clinical and therapeutic features.La Tunisie medicale · 2025Article
- Screening and Identification of Basement Membrane-Related Gene Signatures for Diagnosis in Keratoconus Through WGCNA and Machine Learning.Journal of ophthalmology · 2025Article
- Long-term results of accelerated corneal collagen crosslinking in paediatric patients with progressive keratoconus: 10-year follow-up.Eye (London, England) · 2024Article
- Topographic Keratoconus Incidence in Greece Diagnosed in Routine Consecutive Cataract Procedures: A Consecutive Case Series of 1250 Cases over 5 Years.Journal of clinical medicine · 2024Article
- Mini review: human clinical studies of stem cell therapy in keratoconus.BMC ophthalmology · 2024Review
- Increased inflammatory mediators in the ocular surface tissue in keratoconus.Molecular vision · 2024Article
- Late corneal ectasia after penetrating and deep anterior lamellar keratoplasty for keratoconus.International journal of ophthalmology · 2024Article
- Detecting Keratoconus in Adolescents with Anterior Segment Optical Coherence Tomography.Journal of ophthalmology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Keratoconus is an ectatic corneal disease characterized by progressive stromal thinning, irregular astigmatism, and defective vision. It can be unilateral or bilateral with asymmetric presentation. It starts at puberty and either progresses rapidly to an advanced stage of the disease or stops in case of delayed onset and slow progression. Pediatric keratoconus is more aggressive than in adults and the management protocols differ because of various rationales such as accelerated progression, advanced stage of disease at the time of diagnosis and co-morbidities. It poses a burden to the society as it affects the quality of life, social, and educational development in children. Hence early diagnosis, recognition of progression, and timely intervention with collagen crosslinking is imperative to arrest the worsening. Association with systemic syndromes and ocular comorbidities can be of concern in pediatric keratoconus. Severe ocular allergy when associated hastens progress and complicates timely intervention of crosslinking treatment and compliance to contact lens wear. Keratoplasty in pediatric keratoconus has good outcomes but can encounter frequent suture-related concerns. This article discusses the epidemiology, etiopathogenesis, clinical challenges, and current perspectives of management of pediatric keratoconus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.