Evidence map›Paper›PMID 33463526›Full record

ArticleeLife2021

Yang Lyu, Kristina J Weaver, Humza A Shaukat, Marta L Plumoff, Maria Tjilos, Daniel El Promislow, Scott D Pletcher

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  6. Life-History Trade-Offs in Drosophila: Flies Select a Diet to Maximize Reproduction at the Expense of Lifespan.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yang LyuDepartment of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-4618-9043
Kristina J WeaverDepartment of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, United States.
Humza A ShaukatCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, United States.
Marta L PlumoffCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, United States.
Maria TjilosCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, United States.
Daniel El PromislowDepartment of Lab Medicine & Pathology, University of Washington School of Medicine, Seattle, United States.
Scott D PletcherDepartment of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-4812-3785
University of Michigan · USUniversity of Washington · US

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
Modulation of aging by Sensory PerceptionR01AG030593 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT · 2007 to 2025
$6.1M
Modulation of aging through mechanisms of nutrient demand and rewardR37AG051649 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 2021 to 2026
$2.3M
The role of neural signaling pathways in costs of reproduction on agingR01AG063371 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT, PROMISLOW, DANIEL EDWARD · 2019 to 2023
$1.9M
Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Modulation of aging through mechanisms of nutrient demand and rewardR01AG051649 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT · 2016 to 2020
$1.6M
NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG030593NIA NIH HHS R01 AG049494NIA NIH HHS R01 AG051649NIA NIH HHS R01 AG063371NIA NIH HHS R37 AG051649NIA NIH HHS T32 AG000114
6 · The paper itself

Abstract

It has been recognized for nearly a century that diet modulates aging. Despite early experiments suggesting that reduced caloric intake augmented lifespan, accumulating evidence indicates that other characteristics of the diet may be equally or more influential in modulating aging. We demonstrate that behavior, metabolism, and lifespan in

Indexed as

AgingSignal TransductionAnimalsDietDrosophila melanogasterNutrientsReceptor, Serotonin, 5-HT2ANutrientsReceptor, Serotonin, 5-HT2AagingD. melanogastergeneticsgenomicsmetabolismnutrient choiceserotoninTCA cycle

Identifiers

PMID33463526
PMCPMC7909950
OpenAlexW3122704988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.