ArticleCirculation. Cardiovascular imaging2021
Left Atrial Volumetric/Mechanical Coupling Index: A Novel Predictor of Outcome in Heart Failure With Reduced Ejection Fraction.
Article in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Echocardiography-derived Left Atrial Volumetric-Mechanical Coupling Index predicts early new-onset atrial fibrillation after embolic stroke/transient ischemic attack of undetermined source.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Editorial for "Prognostic Value of a Cardiac Magnetic Resonance-Derived Left Atrioventricular Coupling Index From Routine Cine Images in Dilated Cardiomyopathy: A Multicenter Study".Journal of magnetic resonance imaging : JMRI · 2026Article
- Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Beyond Conventional Echocardiography: The Emerging Role of Left Atrioventricular Coupling Indexes in Chronic Chagas Disease.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Left atrial stiffness, exercise intolerance and injury biomarkers predict adverse outcomes in patients with heart failure with preserved ejection fraction.NPJ cardiovascular health · 2026Article
- Role of imaging techniques in monitoring atrial cardiomyopathy and atrial failure: a scientific statement.ESC heart failure · 2026Review
- Left Atrioventricular Coupling Index: An Echocardiographic Index of Atrioventricular Dysfunction in Dogs with Myxomatous Mitral Valve Disease.Veterinary sciences · 2026Article
- Predictive Value of Preoperative Left Atrial Coupling Indices for Postoperative Atrial Fibrillation After Isolated CABG.Medicina (Kaunas, Lithuania) · 2026Article
- Prognostic and functional value of left atrial indices in advanced heart failure.Cardiovascular ultrasound · 2026Article
- Left Atrial Coupling Index for the Prediction of Atrial Fibrillation and Heart Failure: Current Evidence and Clinical Implications.Current cardiology reports · 2025Review
- A Practical Predictor for Identifying Reverse-Dipper Blood Pressure Patterns: Left Atrial Coupling Index.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Left Atrial Volumetric/Mechanical Coupling Index in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2025Observational
- Left Atrial Volumetric/Mechanical Coupling Index Is Ready for Prime Time Across Clinical Scenarios.Journal of the American Heart Association · 2025Article
- Relationship Between Left Atrial Coupling Index and Atrial High-Rate Episodes.Pacing and clinical electrophysiology : PACE · 2025Article
- Normal reference values of left atrioventricular coupling index on two-Dimensional echocardiography.The international journal of cardiovascular imaging · 2025Article
- Cardiac magnetic resonance left atrioventricular coupling index as a prognostic tool in hypertrophic cardiomyopathy.ESC heart failure · 2025Article
- The role of left atrio-ventricular coupling index and left atrial ejection fraction in predicting onset of atrial fibrillation and adverse cardiac events in hypertrophic cardiomyopathy.Cardiovascular ultrasound · 2025Article
- Left Atrial Function and Incident Heart Failure in Older Adults.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2025Article
- Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2024Article
- Current and Clinically Relevant Echocardiographic Parameters to Analyze Left Atrial Function.Journal of cardiovascular development and disease · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft atrial assessment is complex, particularly in heart failure with reduced ejection fraction due to interactions with functional mitral regurgitation (FMR). Pilot data suggest that left atrial volumetric/mechanical coupling index (LACI) may be useful, but large outcome data are lacking.
methodsWe enrolled a comprehensively characterized cohort of patients in sinus rhythm with heart failure with reduced ejection fraction diagnosis at Mayo Clinic from 2007 to 2011. Routinely measured left atrial volume index and tissue-doppler-imaging a' allowed LACI calculation as (left atrial volume index)/(tissue-doppler-imaging a'). Survival was the outcome measured.
resultsThe cohort's 4196 patients (69 [58-77] years, ejection fraction 40 [31-45]%) had mild FMR in 1505 and moderate-severe FMR in 1068. LACI was overall 5.06 (3.50-8.10) and increased with each FMR grade (3.86 [2.94-5.29] without FMR, 5.38 [3.80-8.02] with mild, 5.45 [1.49-8.07] with moderate/severe FMR;
conclusionsIn this large cohort, left atrial volumetric/mechanical coupling measured by LACI in routine practice integrates the influence of several morphological/hemodynamic determinants but displays progressive deterioration with increasing FMR severity in heart failure with reduced ejection fraction. About outcome, higher LACI is strongly, independently, and incrementally associated with excess mortality, irrespective of FMR grade and in all subsets. Hence, LACI is a novel and critical measure in heart failure with reduced ejection fraction, quantifiable in routine practice, which should be integrated in prognostication and decision-making.
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