ArticleACS biomaterials science & engineering2020
Antimicrobial Bioresorbable Mg-Zn-Ca Alloy for Bone Repair in a Comparison Study with Mg-Zn-Sr Alloy and Pure Mg.
Article in ACS biomaterials science & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Biological Evaluation of Two Magnesium Alloys from Mg-Zn-Mn-Ca and Mg-Nd-Y-Zr-Zn Systems for Bone Repair and Regeneration.Journal of functional biomaterials · 2026Article
- Biodegradable Magnesium-Based Implants in Sports Orthopedic Surgery: Advances in Alloy Design, Surface Engineering, and Translational Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- Mg Alloys Reduce Gastric Cancer and Mediate Therapeutic Management of Antibacterial Function.Journal of functional biomaterials · 2025Article
- Engineering the Ratios of Nanoparticles Dispersed in Triphasic Nanocomposites for Biomedical Applications.ACS applied materials & interfaces · 2025Article
- Recent development and future application of biodegradable ureteral stents.Frontiers in bioengineering and biotechnology · 2024Review
- Article
- Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro.Journal of visualized experiments : JoVE · 2023Article
- In vivo performance of a rare earth free Mg-Zn-Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices.Bioactive materials · 2022Article
- Mg-, Zn-, and Fe-Based Alloys With Antibacterial Properties as Orthopedic Implant Materials.Frontiers in bioengineering and biotechnology · 2022Review
- Article
- Sequence Does Not Matter: The Biomedical Applications of DNA-Based Coatings and Cores.International journal of molecular sciences · 2021Review
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- Recent Advances in Research on Antibacterial Metals and Alloys as Implant Materials.Frontiers in cellular and infection microbiology · 2021Review
- Mechanical properties and biodegradability of Mg-Zn-Ca alloys: homogenization heat treatment and hot rolling.Journal of materials science. Materials in medicine · 2020Article
- Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Magnesium-zinc-calcium (Mg-Zn-Ca) alloys have attracted increasing attention for biomedical implant applications, especially for bone repair, because of their biocompatibility, biodegradability, and similar mechanical properties to human bone. The objectives of this study were to characterize Mg-2 wt % Zn-0.5 wt % Ca (named ZC21) alloy pins microstructurally and mechanically, and determine their degradation and interactions with host cells and pathogenic bacteria in vitro and in vivo in comparison with the previously studied Mg-4 wt % Zn-1 wt % strontium (named ZSr41) alloy and Mg control. Specifically, the in vitro degradation and cytocompatibility of ZC21 pins with bone marrow derived mesenchymal stem cells (BMSCs) were investigated using both direct culture and direct exposure culture methods. The adhesion density of BMSCs on ZC21 pins (i.e., direct contact) was significantly higher than on pure Mg pins in both in vitro culture methods; the cell adhesion density around ZC21 pins (i.e., indirect contact) was similar to the cell-only positive control in both in vitro culture methods. Interestingly, ZC21 showed a higher daily degradation rate, crack width and crack area ratio in the direct exposure culture than in the direct culture, suggesting different culture methods did affect its in vitro degradation behaviors. When cultured with Gram-positive bacteria methicillin-resistant
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