ArticleClinical and translational medicine2021
Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.
Article in Clinical and translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- CAR-CD34 (+) hematopoietic stem/progenitor cells produced in vivo protect against thoracic aortic aneurysm and dissection.Nature communications · 2026Article
- Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target.Molecular biomedicine · 2026Review
- The Regulatory Landscape of Ferroptosis and Iron Homeostasis: Pathophysiological Mechanisms and Therapeutic Horizons in Cardiovascular Disease.Drug design, development and therapy · 2026Review
- Full Blood Count and its Differentials in Acute Aortic Dissection: An Update and Future Perspectives.Aorta (Stamford, Conn.) · 2025Article
- The interplay of ferroptosis and oxidative stress in the pathogenesis of aortic dissection.Frontiers in pharmacology · 2025Review
- Recent advances in the interaction of ferroptosis and immune-mediated inflammation in cardiovascular disease: mechanisms and therapeutic potential.Frontiers in immunology · 2025Review
- [Research progress on the role of ferroptosis in aortic dissection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Review
- Regulated vascular smooth muscle cell death in vascular diseases.Cell proliferation · 2024Review
- Article
- Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection.Molecular medicine (Cambridge, Mass.) · 2024Article
- Iron homeostasis in older adults: balancing nutritional requirements and health risks.The journal of nutrition, health & aging · 2024Review
- The Cdc42/Rac1 pathway: a molecular mechanism behind iron-deficiency-driven aortic medial degeneration.American journal of translational research · 2024Article
- Iron in ventricular remodeling and aneurysms post-myocardial infarction.Open medicine (Warsaw, Poland) · 2024Review
- Review
- Low Zinc Alleviates the Progression of Thoracic Aortic Dissection by Inhibiting Inflammation.Nutrients · 2023Article
- Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases.Nutrients · 2023Review
- Can Iron Play a Crucial Role in Maintaining Cardiovascular Health in the 21st Century?International journal of environmental research and public health · 2022Review
- A Novel Serum Biomarker Model to Discriminate Aortic Dissection from Coronary Artery Disease.Disease markers · 2022Article
- The Study of the Aorta Metallomics in the Context of Atherosclerosis.Biomolecules · 2021Article
- Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.Clinical and translational medicine · 2021Article
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10 authors.
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Abstract
backgroundAortic dissection (AD) and aortic aneurysm (AA) are critical illnesses with an unclear pathogenetic mechanism that seriously threaten human life. Aortic medial degeneration (AMD) is the main pathological feature of AD and AA. Diseases of iron metabolism can cause a variety of physiological dysfunctions. In this study, we aimed to clarify the state of iron metabolism in patients with AD and AA, and to explore the effect of iron metabolism on AMD.
methodsA total of 200 patients with AD or AA, and 60 patients with hypertension were included in the study. Blood samples were drawn immediately when patients were admitted to the hospital. Aortic specimens from patients with Stanford type A AD were obtained at the time of surgery. The status of iron metabolism in the circulation and the aortic wall was analyzed. In addition, apolipoprotein E knockout mice were fed chow with a different iron content, and angiotensin II (Ang II) was used to induce AMD. Furthermore, transferrin receptor 1 knockout (TFR1-/-) mice were used to study the effects of iron deficiency (ID) on aortic development, to observe the effects of different iron metabolism status on the formation of AMD in mice, and to explore the cytoskeleton of vascular smooth muscle cells (VSMCs) under different iron metabolism.
resultsPatients with AMD were iron deficient. ID is associated with the development of AMD in hypertensive patients. Iron-deficient feeding combined with Ang II pumping promoted the formation of AMD and significantly shortened the survival time of mice. ID significantly impaired the cytoskeleton of VSMCs.
conclusionsOur results highlighted that ID was associated with the formation of AMD in patients with hypertension. In this study, we identified a novel mechanism behind VSMCs dysfunction that was induced by ID, thereby suggesting iron homeostasis as a future precaution in patients with hypertension based on its important role in the maintenance of VSMC function.
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