Evidence map›Paper›PMID 33462988›Full record

Trial reportClinical pharmacology in drug development2021

Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective D

Roger L Whiting, Borje Darpo, Chunlin Chen, Margaret Fletcher, Dan Combs, Hongqi Xue, Randall R Stoltz

Open access · hybridAbstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Clinical pharmacology in drug development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Evaluating the Safety, Tolerability, and Disposition of Trazpiroben, a DClinical pharmacology in drug development · 2022
    Trial
  3. Trial
  4. Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  5. Article
  6. Article
  7. Management of Gastroparesis.Gastroenterology & hepatology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Roger L WhitingAltos Therapeutics LLC, Los Altos, California, USA.
Borje DarpoERT, Inc. (previously iCardiac Technologies), Rochester, New York, USA.
Chunlin ChenTakeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
Margaret FletcherMedAssessment, Inc., San Clemente, California, USA.
Dan CombsCombs Consulting Service, Mountain View, California, USA.
Hongqi XueERT, Inc. (previously iCardiac Technologies), Rochester, New York, USA.
Randall R StoltzCovance Laboratories Inc., Clinical Research Unit, Evansville, Indiana, USA.
Integrated Nano-Technologies (United States) · USAltos Therapeutics (United States) · USCovance (United States) · USGlaukos (United States) · USMountain View Clinical Research · USTakeda (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastroparesis is a chronic neuromuscular disorder of the upper gastrointestinal tract in which episodic exacerbation can lead to frequent hospitalizations and severe disability. Dopamine D

Indexed as

AdultDouble-Blind MethodDrug Administration ScheduleFastingFemaleHealthy VolunteersHumansMaleMiddle AgedProlactinTriazolesYoung AdultProlactintrazpirobenTriazolesdopamine D2/D3 selective receptor antagonistsgastroparesispharmacodynamicspharmacokineticssafety

Identifiers

PMID33462988
PMCPMC8451790
OpenAlexW3121285378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.