Evidence map›Paper›PMID 33462889›Full record

ArticleNeurogastroenterology and motility2021

A multicenter study of anorectal pressures and rectal sensation measured with portable manometry in healthy women and men.

Mayank Sharma, Ann C Lowry, Satish S Rao, William E Whitehead, Lawrence A Szarka, Frank A Hamilton, Adil E Bharucha

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Neurogastroenterology and motility, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. High-Resolution Anorectal Manometry and Balloon Expulsion Test Outcomes in Functional Constipation: A Comparative Study.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  3. Optimizing the Utility of Anorectal Manometry for Diagnosis and Therapy: A Roundtable Review and Recommendations.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Review
  4. Review
  5. Faecal incontinence in adults.Nature reviews. Disease primers · 2022
    Review
  6. Review
  7. Diagnostic Strategy and Tools for Identifying Defecatory Disorders.Gastroenterology clinics of North America · 2022
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Mayank SharmaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Ann C LowryColon and Rectal Surgery Associates, Minneapolis, Minnesota, USA.
Satish S RaoDivision of Gastroenterology, Augusta University, Augusta, Georgia, USA.ORCID 0000-0002-4446-8452
William E WhiteheadCenter for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0001-6587-7602
Lawrence A SzarkaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Frank A HamiltonNational Institute of Digestive Diseases, Kidney, and Diabetes, Bethesda, Maryland, USA.
Adil E BharuchaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-7644-0390
Mayo Clinic · USAugusta University · USColon and Rectal Surgery Associates · USNational Institute of Diabetes and Digestive and Kidney Diseases · USUniversity of North Carolina at Chapel Hill · US

Funding

Fecal Incontinence Treatment Study (FIT Study)U01DK115575 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BHARUCHA, ADIL E. · 2018 to 2023
$10.0M
Comparative Effectiveness of Biofeedback, Sacral Nerve Stimulation, and Injectable Bulking Agents for Treatment of Fecal IncontinenceU34DK109191 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BHARUCHA, ADIL E., GANTZ, MARIE G · 2016 to 2017
$711k
NIDDK NIH HHS U01 DK115575NIDDK NIH HHS U34 DK109191
6 · The paper itself

Abstract

backgroundThe equipment and methods for performing anorectal manometry and biofeedback therapy are different and not standardized. Normal values are influenced by age and sex. Our aims were to generate reference values, examine effects of gender and age, and compare anorectal pressures measured with diagnostic and biofeedback catheters and a portable manometry system.

methodsIn this multicenter study, anorectal pressures at rest, during squeeze, and evacuation were measured with diagnostic and biofeedback catheters using Mcompass

resultsThe final dataset comprised 108 (74 women) of 124 participants with normal rectal balloon expulsion time (less than 60 s). During squeeze, anal resting pressure increased by approximately twofold in women and threefold in men. During evacuation, anal pressure exceeded rectal pressure in 87 participants (diagnostic catheter). The specific rectoanal pressures (e.g., resting pressure) were significantly correlated and not different between diagnostic and biofeedback catheters. With the diagnostic catheter, the anal squeeze pressure and rectal pressure during evacuation were greater in men than women (p ≤ 0.02). Among women, women aged 50 years and older had lower anal resting pressure; rectal pressure and the rectoanal gradient during evacuation were greater in older than younger women (p ≤ 0.01).

conclusionsAnal and rectal pressures measured with diagnostic and biofeedback manometry catheters were correlated and not significantly different. Pressures were influenced by age and sex, providing reference values in men and women.

Indexed as

AdultAgedAgingAnal CanalBiofeedback, PsychologyCathetersFecal IncontinenceFemaleHealthy VolunteersHumansMaleManometryMiddle AgedPressureRectumReference Valuesconstipationdefecatory disordersdiagnosisfecal incontinence

Identifiers

PMID33462889
PMCPMC8169521
OpenAlexW3121158103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.