ArticleBiopolymers2021
A high-throughput predictive method for sequence-similar fold switchers.
Article in Biopolymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Embrace Disorder as a Function: Bio-Informed Biomaterials Design Advanced by Intrinsically Disordered Proteins.Biomimetics (Basel, Switzerland) · 2026Article
- Fold-Switching Proteins.Annual review of biophysics · 2026Review
- AnCurrent drug targets · 2026Article
- Morpheus: a fragment-based algorithm to predict fold-switching behaviour in proteins across proteomes.Bioinformatics (Oxford, England) · 2025Article
- Fold-switching proteins.ArXiv · 2025Article
- DivPro: diverse protein sequence design with direct structure recovery guidance.Bioinformatics (Oxford, England) · 2025Article
- Origin and Evolution of Bacterial Periplasmic Force Transducers.Molecular biology and evolution · 2025Article
- Fluid protein fold space and its implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Article
- Metamorphic protein folding as evolutionary adaptation.Trends in biochemical sciences · 2023Review
- Identification of a covert evolutionary pathway between two protein folds.Nature communications · 2023Article
- Distinguishing features of fold-switching proteins.Protein science : a publication of the Protein Society · 2023Review
- Evolutionary selection of proteins with two folds.bioRxiv : the preprint server for biology · 2023Article
- Many dissimilar NusG protein domains switch between α-helix and β-sheet folds.Nature communications · 2022Article
- AlphaFold2 fails to predict protein fold switching.Protein science : a publication of the Protein Society · 2022Article
- Design and discovery of metamorphic proteins.Current opinion in structural biology · 2022Review
- Metamorphic proteins under a computational microscope: Lessons from a fold-switching RfaH protein.Computational and structural biotechnology journal · 2022Review
- A high-throughput predictive method for sequence-similar fold switchers.Biopolymers · 2021Article
- A sequence-based method for predicting extant fold switchers that undergo α-helix ↔ β-strand transitions.Biopolymers · 2021Article
- Predictable fold switching by the SARS-CoV-2 protein ORF9b.Protein science : a publication of the Protein Society · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Although most experimentally characterized proteins with similar sequences assume the same folds and perform similar functions, an increasing number of exceptions is emerging. One class of exceptions comprises sequence-similar fold switchers, whose secondary structures shift from α-helix <-> β-sheet through a small number of mutations, a sequence insertion, or a deletion. Predictive methods for identifying sequence-similar fold switchers are desirable because some are associated with disease and/or can perform different functions in cells. Here, we use homology-based secondary structure predictions to identify sequence-similar fold switchers from their amino acid sequences alone. To do this, we predicted the secondary structures of sequence-similar fold switchers using three different homology-based secondary structure predictors: PSIPRED, JPred4, and SPIDER3. We found that α-helix <-> β-strand prediction discrepancies from JPred4 discriminated between the different conformations of sequence-similar fold switchers with high statistical significance (P < 1.8*10
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