ArticleDigestive diseases and sciences2021
The Sphincter of O'Beirne-Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia.
Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Ingesting yeast extract causes excitation of neurogenic and myogenic colonic motor patterns in the rat.Journal of cellular and molecular medicine · 2024Article
- Faecal incontinence is associated with an impaired rectosigmoid brake and improved by sacral neuromodulation.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Diagnosis of colonic dysmotility associated with autonomic dysfunction in patients with chronic refractory constipation.Scientific reports · 2022Article
- The role of colonic motility in low anterior resection syndrome.Frontiers in oncology · 2022Review
- Intraoperative serosal extracellular mapping of the human distal colon: a feasibility study.Biomedical engineering online · 2021Article
- The Sphincter of O'Beirne - Part 1: Study of 18 Normal Subjects.Digestive diseases and sciences · 2021Article
- A novel mechanism for acute colonic pseudo-obstruction revealed by high-resolution manometry: A case report.Physiological reports · 2021Article
- Distal Colon Motor Coordination: The Role of the Coloanal Reflex and the Rectoanal Inhibitory Reflex in Sampling, Flatulence, and Defecation.Frontiers in medicine · 2021Article
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Authors and funding
8 authors at 1 institution in 2 countries.
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Abstract
backgroundChronic constipation can have one or more of many etiologies, and a diagnosis based on symptoms is not sufficient as a basis for treatment, in particular surgery.
aimTo investigate the cause of chronic constipation in a patient with complete absence of spontaneous bowel movements.
methodsHigh-resolution colonic manometry was performed to assess motor functions of the colon, rectum, the sphincter of O'Beirne and the anal sphincters.
resultsNormal colonic motor patterns were observed, even at baseline, but a prominent high-pressure zone at the rectosigmoid junction, the sphincter of O'Beirne, was consistently present. In response to high-amplitude propagating pressure waves (HAPWs) that were not consciously perceived, the sphincter and the anal sphincters would not relax and paradoxically contract, identified as autonomous dyssynergia. Rectal bisacodyl evoked marked HAPW activity with complete relaxation of the sphincter of O'Beirne and the anal sphincters, indicating that all neural pathways to generate the coloanal reflex were intact but had low sensitivity to physiological stimuli. A retrograde propagating cyclic motor pattern initiated at the sphincter of O'Beirne, likely contributing to failure of content to move into the rectum.
conclusionsChronic constipation without the presence of spontaneous bowel movements can be associated with normal colonic motor patterns but a highly exaggerated pressure at the rectosigmoid junction: the sphincter of O'Beirne, and failure of this sphincter and the anal sphincters to relax associated with propulsive motor patterns. The sphincter of O'Beirne can be an important part of the pathophysiology of chronic constipation.
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