ArticleNature metabolism2021
Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism.
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Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
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Who cites it
57 citing papers in PubMed, 81 citations in OpenAlex.
- Phenylacetic Acid, a Gut Microbially Produced Metabolite, Reduces Atherosclerosis Burden and Impacts Host Lipid Homeostasis.Journal of the American Heart Association · 2026Article
- Genetic or pharmacological inhibition of hepatic TMEM141 attenuates MASH and fibrosis via the ROS-HNF4α signaling pathway.Nature communications · 2026Article
- Deletion of activating transcription factor 3 (Atf3) promotes cardiomyocyte differentiation from embryonic stem cells.Scientific reports · 2026Article
- Yifei Sanjie Formula in improving the response to PD-1 blockade by lung cancer through the attenuation of the USP7-NR1H4-bile acid metabolism axis.Journal of thoracic disease · 2026Article
- Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease.Annals of clinical and translational neurology · 2026Article
- Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice.International journal of molecular sciences · 2026Article
- Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Activating transcription factors: Orchestrators of macrophage biology in pathological settings (Review).International journal of molecular medicine · 2026Review
- Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and short-term outcomes in hepatitis B virus-related acute-on-chronic liver failure.BMC infectious diseases · 2026Article
- Integrated bioinformatics analysis and experimental validation ofFrontiers in molecular biosciences · 2026Article
- Emerging insights of bile acids in cardiovascular physiology and disease: from molecular mechanisms to therapeutic potential.Frontiers in pharmacology · 2026Review
- ATF3 and HNF4A: an oxidative phosphorylation and cholesterol homeostasis-associated diagnostic and therapeutic repurposing framework target for metabolic dysfunction-associated steatohepatitis patients.Frontiers in medicine · 2026Article
- An ATF3 Inducer Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease Through the AMPK and PKA Pathways.International journal of molecular sciences · 2025Article
- Hepatic activating transcription factor 3 protects against systemic inflammation by attenuating lipotoxicity.Metabolism open · 2025Article
- ATF3 Deficiency Exacerbates Ageing-Induced Atherosclerosis and Clinical Intervention Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Hepatic Mechanisms of Myocardial Infarction: A New Perspective in Metabolic Dysfunction-Associated Fatty Liver Disease.Journal of the American Heart Association · 2025Review
- Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers.Cell genomics · 2025Article
- Beyond weight loss: exploring bile acid modulations after bariatric surgery and their impact on type 2 diabetes across 5 years.Obesity (Silver Spring, Md.) · 2025Article
- Article
- Activating transcription factor 3 regulates hepatic apolipoprotein A4 upon metabolic stress.The Journal of biological chemistry · 2025Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Yanyong Xu *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Yuanyuan Li *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Kavita Jadhav *Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Xiaoli PanDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.ORCID http://orcid.org/0000-0002-5033-7272
Yingdong ZhuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Shuwei HuDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Shaoru ChenDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Liuying ChenDivison of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yong TangDepartment of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Helen H WangDepartment of Medicine and Genetics, Marion Bessin Liver Research Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Ling YangDivison of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-0751-5600
David Q-H WangDepartment of Medicine and Genetics, Marion Bessin Liver Research Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Liya YinDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.
Yanqiao ZhangDepartment of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA. yzhang@neomed.edu.ORCID http://orcid.org/0000-0002-1886-7775
Northeast Ohio Medical University · USUnion Hospital · CNAlbert Einstein College of Medicine · USChinese Academy of Sciences · CN
Funding
Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK102619 · NIDDK · UNIVERSITY OF ARIZONA · PI Yanqiao Zhang · 2015 to 2026
$4.0MRegulation of Lipid and Lipoprotein Metabolism by Nuclear ReceptorsR01HL103227 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI YIN, LIYA, ZHANG, YANQIAO · 2011 to 2019
$3.1MIdentification of Novel Genes/Pathways That Regulate AtherogenesisR01HL142086 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2018 to 2021
$2.1MHepatic FOXA3 Links NAFLD to AtherosclerosisR01DK118805 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2019 to 2022
$2.0MGPR30 and hepatic cholesterol metabolismR01DK126369 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PESSIN, JEFFREY E. · 2020 to 2023
$1.9MRole of Hepatocyte ATF3 in NAFLDR01DK118941 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2018 to 2021
$1.8MApolipoprotein A5 and Gallstone FormationR01DK114516 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WANG, DAVID Q · 2018 to 2021
$1.5MIdentification of Novel Genes/Pathways That Regulate Lipid and Glucose MetabolismR01DK095895 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, YANQIAO · 2012 to 2015
$1.3MGPR30 and Hepatic Cholesterol HomeostasisR01DK106249 · NIDDK · SAINT LOUIS UNIVERSITY · PI WANG, DAVID Q · 2015 to 2017
$1.0MNHLBI NIH HHS R01 HL103227NHLBI NIH HHS R01 HL142086NIDDK NIH HHS R01 DK095895NIDDK NIH HHS R01 DK102619NIDDK NIH HHS R01 DK106249NIDDK NIH HHS R01 DK114516NIDDK NIH HHS R01 DK118805NIDDK NIH HHS R01 DK118941NIDDK NIH HHS R01 DK126369
Abstract
Activating transcription factor (ATF)3 is known to have an anti-inflammatory function, yet the role of hepatic ATF3 in lipoprotein metabolism or atherosclerosis remains unknown. Here we show that overexpression of human ATF3 in hepatocytes reduces the development of atherosclerosis in Western-diet-fed Ldlr
Indexed as
Activating Transcription Factor 3AnimalsApolipoproteins EAtherosclerosisBile Acids and SaltsCholesterol, DietaryDietary FatsGene Expression RegulationHepatocyte Nuclear Factor 4HepatocytesHumansHydrocortisoneLipoproteins, HDLMaleMiceMice, Inbred C57BLActivating Transcription Factor 3Apoe protein, mouseApolipoproteins EATF3 protein, humanBile Acids and SaltsCholesterol, DietaryDietary FatsHepatocyte Nuclear Factor 4HydrocortisoneLipoproteins, HDLReceptors, LDLScarb1 protein, mouseScavenger Receptors, Class BSteroid 12-alpha-HydroxylaseTumor Suppressor Protein p53
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