ArticleNature genetics2021
Large-scale association analyses identify host factors influencing human gut microbiome composition.
Open access · bronzeAbstract read
In one paragraph
Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,125 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,125citing papers in PubMed, 6 pooled it
121.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1,125 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,775 citations in OpenAlex.
- Investigating the shared genetic architecture between inflammatory bowel disease and pancreatitis: a genome-wide cross-trait analysis.Molecular genetics and genomics : MGG · 2026Pooled it
- Fecal microbiota transplantation from psychiatric patients to mice - systematic review of methodologies and a call for standardization.Translational psychiatry · 2026Pooled it
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Causal risk and protective factors for rheumatoid arthritis: a comprehensive mendelian randomization systematic review and meta-analysis.Frontiers in genetics · 2026Pooled it
- The microbiota-gut-brain-epigenome axis as a novel therapeutic target for decoding postpartum depression.Frontiers in medicine · 2026Pooled it
- Worldwide research trends on theFrontiers in immunology · 2026Pooled it
- Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2026Trial
- Trial
- Effects of a combined energy restriction and vigorous-intensity exercise intervention on the human gut microbiome: A randomised controlled trial.The Journal of physiology · 2025Trial
- Hypertension and gut microbial hydrogenases: a comparison of hydrogen metabolism and etiology.Medical gas research · 2026Article
- Genetically Predicted Gut Microbial Taxa and Inflammatory Proteins Associated With Atrial Fibrillation: A Bidirectional Mendelian Randomization and Colocalization Study.Journal of arrhythmia · 2026Article
- Bibliometric analysis of research trends and hotspots on the microbial mediation effects.Antonie van Leeuwenhoek · 2026Article
- Circulating asparagine and short stature: A case-control study and exploratory two-sample Mendelian randomization analysis.Medicine · 2026Article
- Global and local trajectories of infant gut microbiota development in Bangladesh across the COVID-19 pandemic.mSystems · 2026Article
- Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk.Nature metabolism · 2026Article
- Gut microbiome dysbiosis is associated with aldosterone overproduction in idiopathic hyperaldosteronism.iScience · 2026Article
- Integrative multi-omics analyses suggest a candidate microbial metabolite-associated host gene network in ulcerative colitis.Immunologic research · 2026Article
- Association of composite inflammatory indicators with osteoporosis and sarcopenia in type 2 diabetes mellitus: the mediating role of inflammation.Journal of endocrinological investigation · 2026Article
- Genetic dissection of the eggplant rhizosphere microbiome enables microbiome-assisted breeding.Horticulture research · 2026Article
- Two-sample Mendelian randomization study of gut microbiota and inflammatory proteins: Predictive, preventive, and personalized treatment for migraine.Neural regeneration research · 2026Article
1,065 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
104 authors at 20 institutions in 17 countries.
Alexander Kurilshikov *Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. alexa.kur@gmail.com.ORCID http://orcid.org/0000-0003-2541-5627
Carolina Medina-Gomez *Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7999-5538
Rodrigo Bacigalupe *Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7310-997X
Djawad Radjabzadeh *Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jun Wang *Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.
Ayse DemirkanDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Caroline I Le RoyDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0341-751X
Juan Antonio Raygoza GarayDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-4296-4118
Casey T FinnicumAvera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
Xingrong LiuCenter for Molecular Medicine and Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0199-0221
Daria V ZhernakovaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Tue H HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5948-8993
Fabian FrostDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Malte C RühlemannInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-0685-0052
Williams TurpinDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-9364-5868
Jee-Young MoonDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Han-Na KimMedical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-7053-7469
Kreete LüllEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-9722-5876
Elad BarkanDepartment of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-6176-3293
Shiraz A ShahCOPSAC, Copenhagen University Hospital, Copenhagen, Denmark.
Myriam FornageInstitute of Molecular Medicine McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Joanna Szopinska-TokovDepartment of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Zachary D WallenDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-2278-7348
Dmitrii BorisevichNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1686-3578
Lars AgreusDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Anna AndreassonStress Research Institute, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0203-7977
Corinna BangInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Larbi BedraniDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Jordana T BellDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3858-5986
Hans BisgaardCOPSAC, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4131-7592
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Dorret I BoomsmaBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Robert D BurkDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.
Annique ClaringbouldDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-9201-6557
Kenneth CroitoruDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.
Gareth E DaviesAvera Institute of Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Liesbeth DuijtsThe Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Gwen FalonyDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2450-0782
Jingyuan FuDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Adriaan van der GraafDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-8898-8484
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-8748-3831
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
David A HughesMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-9644-8998
Richard G IjzermanDepartment of Endocrinology, Amsterdam University Medical Center, location VUMC, Amsterdam, the Netherlands.
Matthew A JacksonDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7891-6217
Vincent W V JaddoeThe Generation R Study, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Marie JoossensDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.
Torben JørgensenCentre for Clinical Research and Prevention, Bispebjerg/Frederiksberg Hospital, Capital Region of Copenhagen and Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Daniel KeszthelyiDivision of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Rob KnightDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3394-7749
Matthias LaudesDepartment of Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-7846-955X
Lenore J LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Aldons J LusisDepartments of Microbiology, Immunology and Molecular Genetics, and Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-9013-0228
Ad A M MascleeDivision of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Henriette A MollDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Zlatan MujagicDivision of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Qi QibinDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Daphna RothschildDepartment of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-0872-8624
Hocheol ShinDepartment of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Søren J SørensenDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6227-9906
Claire J StevesDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Jonathan ThorsenCOPSAC, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-0200-0461
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7141-9189
Raul Y TitoDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9660-7621
Sara Vieira-SilvaDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-4616-7602
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Urmo VõsaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0003-3476-1652
Kaitlin H WadeMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-3362-6280
Susanna WalterDepartment of Biomedical and Clinical Sciences, University of Linköping, Linköping, Sweden.
Kyoko WatanabeDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3303-8860
Stefan WeissDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Frank U WeissDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Omer WeissbrodSchool of Public Health, Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9860-0626
Harm-Jan WestraDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-7038-567X
Gonneke WillemsenBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Haydeh PayamiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-9084-5338
Daisy M A E JonkersDivision of Gastroenterology-Hepatology, Maastricht University Medical Center+, Maastricht, the Netherlands.
Alejandro Arias VasquezDepartment of Psychiatry, Radboudumc, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Eco J C de GeusBiological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Katie A MeyerDepartment of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jakob StokholmCOPSAC, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-4989-9769
Eran SegalDepartment of Computer Science and Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0002-6859-1164
Elin OrgEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-5635-1614
Hyung-Lae KimDepartment of Biochemistry, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
Robert C KaplanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9795-0365
Andre G UitterlindenDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-9643-8263
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Serena SannaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-3768-1749
Mauro D'AmatoCenter for Molecular Medicine and Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2743-5197
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3321-3972
Andrew D PatersonGenetics and Genome Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
Robert KraaijDepartment of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jeroen RaesDepartment of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-1337-041X
Alexandra ZhernakovaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. sasha.zhernakova@gmail.com.ORCID http://orcid.org/0000-0002-4574-0841
University Medical Center Groningen · NLErasmus MC · NLUniversitätsmedizin Greifswald · DERega Institute for Medical Research · BEUniversity of Copenhagen · DKKing's College London · GBChristian-Albrechts-Universität zu Kiel · DECopenhagen University Hospital · DKMaastricht University · NLAlbert Einstein College of Medicine · USAt Bristol · GBMount Sinai Hospital · CAWeizmann Institute of Science · ILAvera McKennan Hospital & University Health Center · USEwha Womans University · KRKarolinska Institutet · SERadboud University Nijmegen · NLUniversity of Alabama at Birmingham · USUniversity of Tartu · EEVrije Universiteit Amsterdam · NL
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MRe-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MUNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6MCANDIDATE GENE ASSOCIATION RESOURCE (CARE)N01HC65226 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2009
$17.0MHispanic Community Health Study - NIDCDN01HC65235 · NHLBI · YESHIVA UNIVERSITY · PI KAPLAN, ROBERT · 2007 to 2012
$16.0MOTHER FUNCTIONS - R&D - HISPANIC COMMUNITY HEALTH STUDYN01HC65233 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAI, JAIWEN · 2007 to 2012
$15.1MHISPANIC COMMUNITY HEALTH STUDY - FIELD CENTERN01HC65236 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DIVIGLUS, MARTHA · 2007 to 2012
$13.4MHISPANIC COMMUNITY HEALTH STUDY - FIELD CENTERN01HC65234 · NHLBI · UNIVERSITY OF MIAMI CORAL GABLES · PI SCHNEIDERMAN, NEIL · 2007 to 2012
$13.1MHISPANIC COMMUNITY HEALTH STUDY - FIELD CENTERN01HC65237 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI TALAVERA, GREGORY · 2007 to 2013
$12.4MIdentifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MIdentifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7MCancer Research UK 19169Cancer Research UK 29019Cancer Research UK C18281/A19169Department of Health BRC-1215-20011Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/3Medical Research Council MR/N01183X/1Medical Research Council MR/N030125/1NCATS NIH HHS UL1 TR002489NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS K01 HL127159NHLBI NIH HHS N01HC65226NHLBI NIH HHS N01HC65233NHLBI NIH HHS N01HC65234NHLBI NIH HHS N01HC65235NHLBI NIH HHS N01HC65236NHLBI NIH HHS N01HC65237NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL140976NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK062370NIDDK NIH HHS R01 DK092127NIDDK NIH HHS U01 DK062370NIMHD NIH HHS R01 MD011389NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457NINDS NIH HHS T32 NS095775Wellcome Trust 202802/Z/16/ZWellcome Trust 204813/Z/16/Z
Abstract
To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 × 10
Indexed as
Genetic VariationQuantitative Trait LociAdolescentAdultBifidobacteriumChildChild, PreschoolCohort StudiesFemaleGastrointestinal MicrobiomeGenome-Wide Association StudyHumansLactaseLinkage DisequilibriumMaleMendelian Randomization AnalysisLactaseRNA, Ribosomal, 16S
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