ArticleNature genetics2021
Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
Abstract read
In one paragraph
Article in Nature genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 4 pooled it
15.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 4 syntheses or guidelines pooled it, 233 citations in OpenAlex.
- Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm.The Journal of international medical research · 2026Pooled it
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.Briefings in bioinformatics · 2025Pooled it
- Pooled it
- A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.Annals of medicine · 2026Review
- Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- The associations of human genetic variations with airway microbiome, environmental exposures, and respiratory health.mSystems · 2026Article
- FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.Molecular and cellular biochemistry · 2026Article
- Potential role of Akkermansia massiliensis in multiple sclerosis protection by the FcRL3 gene.Genes and immunity · 2026Article
- FUT2-mediated α1,2-fucosylation in inflammatory bowel disease: mechanisms and translational potential.Molecular biology reports · 2026Review
- A Principled Framework for Mendelian Randomization in Oral Health Research.Journal of periodontal research · 2026Article
- Neurobehavioural genes exert indirect genetic effects on blood lipid profiles through behavioural traits.Communications biology · 2026Article
- Gut-reproduction axis: genome-wide pleiotropic and prospective evidence linking inflammatory bowel disease with gynecological disorders.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Impact of gut microbiome, plasma metabolites, peripheral immune cells, and circulating inflammatory protein on chronic spontaneous urticaria: Bidirectional 2-sample Mendelian randomization study and mediation analysis.The journal of allergy and clinical immunology. Global · 2026Article
- Cytokine Gene Polymorphisms Modulate Isohemagglutinin Titers and Classes: Another Aspect Towards the Link Between ABO Groups and Human Pathologies?International journal of molecular sciences · 2026Article
- Collaboration of the symbiotic microbiome and host genome during the high altitude adaptation of chickens.Science China. Life sciences · 2026Article
- Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases.Journal of biomedical research · 2026Article
- Article
- A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases.Nature communications · 2026Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 4 institutions in 1 country.
Malte Christoph RühlemannInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0002-0685-0052
Britt Marie HermesEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.
Corinna BangInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Shauni DomsEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.ORCID http://orcid.org/0000-0002-2129-4138
Lucas Moitinho-SilvaInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Louise Bruun ThingholmInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Fabian FrostDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Frauke DegenhardtInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Michael WittigInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Jan KässensInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0001-7840-1160
Frank Ulrich WeissDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Klaus NeuhausZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-6020-2814
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Henry VölzkeDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Georg HomuthDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Stefan WeissDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Harald GrallertInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Matthias LaudesDepartment of Internal Medicine 1, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0002-7846-955X
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Dirk HallerZIEL-Institute for Food & Health, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0002-6977-4085
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-9643-8263
John F BainesEvolutionary Genomics, Max Planck Institute for Evolutionary Biology, Plön, Germany.ORCID http://orcid.org/0000-0002-1372-8426
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany. a.franke@mucosa.de.ORCID http://orcid.org/0000-0003-1530-5811
Christian-Albrechts-Universität zu Kiel · DEUniversitätsmedizin Greifswald · DEHelmholtz Zentrum München · DELeibniz-Institute for Food Systems Biology at the Technical University of Munich · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory
Indexed as
ABO Blood-Group SystemBacteroidesFaecalibacteriumFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGastrointestinal MicrobiomeGenome-Wide Association StudyGermanyHumansLactaseLinkage DisequilibriumMendelian Randomization AnalysisABO Blood-Group SystemFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseLactase
Identifiers
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Textmetadata
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.