Evidence map›Paper›PMID 33462454›Full record

ArticleNature immunology2021

Gut CD4

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Dynamics and variegation in the Treg response to Interleukin-2.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. CD4Nature immunology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The dual nature of TFEBS letters · 2025
    Review
  20. Article

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Evgeny KinerDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Elijah WillieBioinformatics Program, University of British Columbia, Vancouver, British Columbia, Canada.
Brinda VijaykumarDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Kaitavjeet ChowdharyDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Hugo SchmutzDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Jodie ChandlerMalaghan Institute of Medical Research, Wellington, New Zealand.
Alexandra SchnellEvergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Pratiksha I ThakoreKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Graham LeGrosMalaghan Institute of Medical Research, Wellington, New Zealand.
Sara MostafaviDepartments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.ORCID http://orcid.org/0000-0002-6110-4626
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.ORCID http://orcid.org/0000-0003-1172-6555
Immunological Genome Project Consortium

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
ImmGen: Gene Expression and Regulation in Immune CellsR24AI072073 · NIAID · JOSLIN DIABETES CENTER · PI CHRISTOPHE O. BENOIST · 2007 to 2026
$28.5M
T regulatory cell subsets at the microbial interface: determinism and functionR01AI125603 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2017 to 2021
$2.1M
Targeted DNA extraction for Tuberculosis PCR from sputumR41AI073072 · NIAID · PHTHISIS DIAGNOSTICS · PI HOUPT, ERIC R · 2007 to 2007
$275k
NIAID NIH HHS R01 AI125603NIAID NIH HHS R24 AI072073NIAID NIH HHS R41 AI073072NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

CD4

Indexed as

Gastrointestinal MicrobiomeAnimalsBacteriaBacterial InfectionsCD4-Positive T-LymphocytesChromatinCitrobacter rodentiumColonCytokinesDisease Models, AnimalGene Expression ProfilingHeligmosomatoideaHost-Pathogen InteractionsInterferon Regulatory FactorsIntestinal Diseases, ParasiticMaleChromatinCytokinesInterferon Regulatory FactorsTranscription Factor AP-1

Identifiers

PMID33462454
PMCPMC7839314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.