ArticleNature medicine2021
State-dependent responses to intracranial brain stimulation in a patient with depression.
Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06347978 (A Double-Blinded, Randomized, Crossover Trial of Stereoencephalography- Guided Four-Lead Personalized Deep Brain Stimulation for Treatment-Refractory Obsessive Compulsive Disorder), which is not on this map. Cited by 120 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double-Blinded, Randomized, Crossover Trial of Stereoencephalography- Guided Four-Lead Personalized Deep Brain Stimulation for Treatment-Refractory Obsessive Compulsive Disorder (SEEG-Guided DBS for OCD)
Who cites it
120 citing papers in PubMed, 226 citations in OpenAlex.
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Deep Brain Stimulation for Depression Informed by Intracranial Recordings.Biological psychiatry · 2022Trial
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Technical system of electroencephalography-based brain-computer interface: Advances, applications, and challenges.Neural regeneration research · 2026Article
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- State-Dependent Modulation of a Theta-Responsive Subnetwork by High-Frequency Stimulation of the Ventral Striatum.Neuroscience bulletin · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- NAcLat-DBS reduces GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Preliminary clinical and electrophysiological findings of NAc/ALIC deep brain stimulation strategy for treatment-resistant depression.iScience · 2026Article
- Bayesian-enhanced closed-loop optimization of ultrasound protocols for targeted and precise neuromodulation.bioRxiv : the preprint server for biology · 2026Article
- A week in the life of the human brain reveals stable states punctuated by chaotic-like transitions.Nature communications · 2026Article
- Article
- Has Deep Brain Stimulation Shown Its Full Potential in Treatment-Resistant Depression? A Scoping Review.Biological psychiatry global open science · 2026Review
- Review
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Human orbitofrontal neural activity is linked to obsessive-compulsive behavioral dynamics.Cell · 2026Article
- Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls.Translational psychiatry · 2026Article
- Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder.Nature communications · 2026Article
- State-dependent modulation of brain co-activation patterns induced by individually targeted VLPFC stimulation during viewing emotional film clips.Frontiers in human neuroscience · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.