ArticleNature microbiology2021
Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy.
RetractedOpen access · greenAbstract readRetracted Publication
In one paragraph
Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- The Microbial Trojan Horse and Antimicrobial Resistance: Acanthamoeba as an Environmental Reservoir for Multidrug Resistant Bacteria.Environmental microbiology · 2025Article
- The host calcium system contributes to intracellularInfection and immunity · 2025Article
- Mitochondrial calcium uniporter promotes MSU crystal-induced inflammation through inducing mitochondrial CaArthritis research & therapy · 2025Article
- Cross-membrane cooperation among bacteria can facilitate intracellular pathogenesis.Nature communications · 2025Article
- RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages.bioRxiv : the preprint server for biology · 2025Article
- Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival.Journal of translational medicine · 2025Article
- Pathogen-induced mitochondrial dysfunction: mechanistic insights, immune crosstalk, and therapeutic opportunities.Frontiers in cellular and infection microbiology · 2025Review
- The MICOS Complex Subunit Mic60 is Hijacked by Intracellular Bacteria to Manipulate Mitochondrial Dynamics and Promote Bacterial Pathogenicity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense.Nature communications · 2024Article
- The mitochondrial carboxylase PCCA interacts withApplied and environmental microbiology · 2024Article
- CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2iScience · 2024Article
- Article
- Multifaceted mitochondria in innate immunity.npj metabolic health and disease · 2024Review
- The ketone body β-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-β oligomer-induced inflammation in human microglia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Article
- Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging.Nature aging · 2023Article
- AUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.Autophagy reports · 2023Article
- Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation.Frontiers in immunology · 2023Review
- Beyond autophagy: LC3-associated phagocytosis and endocytosis.Science advances · 2022Review
- LC3-associated endocytosis and the functions of Rubicon and ATG16L1.Science advances · 2022Review
- LC3-Associated Phagocytosis in Bacterial Infection.Pathogens (Basel, Switzerland) · 2022Review
Corrections and comments
- Retracted
Authors and funding
22 authors at 8 institutions in 2 countries.
Tianliang Li *Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Ligang Kong *Shandong Institute of Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Xinghui LiDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Sijin WuCollege of Pharmacy, Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH, USA.
Kuldeep S AttriEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.
Yan LiDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
Weipeng GongDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Bao ZhaoDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
Lupeng LiDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Laura E HerringProteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
John M AsaraDivision of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA, USA.
Lei XuShandong Institute of Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
Xiaobo LuoDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Yu L LeiDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9868-9824
Qin MaDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Stephanie SeveauDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA.
John S GunnCenter for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Xiaolin ChengCollege of Pharmacy, Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH, USA.
Pankaj K SinghEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0001-8903-0131
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Haibo WangShandong Institute of Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China. whboto11@163.com.ORCID http://orcid.org/0000-0003-0955-9532
Haitao WenDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA. Haitao.Wen@osumc.edu.ORCID http://orcid.org/0000-0002-6363-2748
The Ohio State University · USShandong University · CNUniversity of Michigan · USUniversity of Nebraska Medical Center · USUniversity of North Carolina at Chapel Hill · USBeth Israel Deaconess Medical Center · USNationwide Children's Hospital · USSt. Jude Children's Research Hospital · US
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6MVirology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MMECHANISMS OF REGULATED CELL DEATHR35CA231620 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2018 to 2026
$9.2MNon-canonical functions of autophagy proteinsR01AI040646 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1997 to 2023
$8.6MTargeting Tumor-Stromal Metabolic Cross-Talk in Pancreatic CancerR01CA163649 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Pankaj Kumar Singh · 2012 to 2026
$5.4MSurvival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5MRestoring the Immunogenicity of Head and Neck CancerR01DE026728 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Yu Leo Lei, James J. Moon · 2018 to 2026
$4.3MRobust Immuno-prevention Strategies for High-Risk Oral Epithelial DysplasiaU01DE029255 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRENNER, JOHN CHADWICK, LEI, YU LEO · 2019 to 2021
$4.2MMetabolic Regulation of Tumor Progression, Metastasis and Chemoresistance by SIRT5/ELK3 signaling in Pancreatic CancerR01CA216853 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SINGH, PANKAJ KUMAR · 2017 to 2021
$2.6MTargeting the Metabolic Basis of Cachexia in Pancreatic CancerR01CA210439 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SINGH, PANKAJ KUMAR · 2017 to 2021
$2.6MMultifaceted activity of listeriolysin O during host cell invasion by ListeriaR01AI107250 · NIAID · OHIO STATE UNIVERSITY · PI SEVEAU, STEPHANIE M M · 2014 to 2018
$1.9MNCI NIH HHS P01 CA120964NCI NIH HHS P30 CA006516NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA163649NCI NIH HHS R01 CA210439NCI NIH HHS R01 CA216853NCI NIH HHS R35 CA231620NIAID NIH HHS R01 AI040646NIAID NIH HHS R01 AI107250NIAID NIH HHS R37 AI044828NIDCR NIH HHS R01 DE026728NIDCR NIH HHS U01 DE029255NIGMS NIH HHS R01 GM120496NIGMS NIH HHS R01 GM135234
Abstract
Mitochondria are believed to have originated ~2.5 billion years ago. As well as energy generation in cells, mitochondria have a role in defence against bacterial pathogens. Despite profound changes in mitochondrial morphology and functions following bacterial challenge, whether intracellular bacteria can hijack mitochondria to promote their survival remains elusive. We report that Listeria monocytogenes-an intracellular bacterial pathogen-suppresses LC3-associated phagocytosis (LAP) by modulation of mitochondrial Ca
Indexed as
Calcium SignalingPhagocytosisAcetylationAcetyl Coenzyme AAnimalsAutophagy-Related ProteinsCalciumCalcium ChannelsHost-Pathogen InteractionsHumansListeria monocytogenesMacrophagesMiceMicrotubule-Associated ProteinsMitochondriaMutationAcetyl Coenzyme AAutophagy-Related ProteinsCalciumCalcium ChannelsMicrotubule-Associated Proteinsmitochondrial calcium uniporterNADPH Oxidases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.