ArticleCell research2021
A novel somatosensory spatial navigation system outside the hippocampal formation.
Article in Cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 13 citations in OpenAlex.
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- The perforant pathway and CA3-Schaffer collateral afferents coordinate to regulate spatial learning.Communications biology · 2026Article
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation.Research (Washington, D.C.) · 2026Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- All active hippocampal pyramidal cells are place cells.iScience · 2025Article
- A Hippocampal-Parietal Network for Reference Frame Coordination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hand position fields of neurons in the premotor cortex of macaques during natural reaching.Nature communications · 2025Article
- Perirhinal cortex abnormalities impair hippocampal plasticity and learning inScience advances · 2025Article
- Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex.Nature communications · 2025Article
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- APOE ɛ4 and Insulin Resistance Influence Path-Integration-Based Navigation through Distinct Large-Scale Network Mechanisms.Aging and disease · 2024Article
- Olfactory bulb tracks breathing rhythms and place in freely behaving mice.bioRxiv : the preprint server for biology · 2024Article
- Eliminating episodic memory?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Intrinsic Bipolar Head-Direction Cells in the Medial Entorhinal Cortex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Border cells without theta rhythmicity in the medial prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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2 authors at 2 institutions in 1 country.
Funding
Abstract
Spatially selective firing of place cells, grid cells, boundary vector/border cells and head direction cells constitutes the basic building blocks of a canonical spatial navigation system centered on the hippocampal-entorhinal complex. While head direction cells can be found throughout the brain, spatial tuning outside the hippocampal formation is often non-specific or conjunctive to other representations such as a reward. Although the precise mechanism of spatially selective firing activity is not understood, various studies show sensory inputs, particularly vision, heavily modulate spatial representation in the hippocampal-entorhinal circuit. To better understand the contribution of other sensory inputs in shaping spatial representation in the brain, we performed recording from the primary somatosensory cortex in foraging rats. To our surprise, we were able to detect the full complement of spatially selective firing patterns similar to that reported in the hippocampal-entorhinal network, namely, place cells, head direction cells, boundary vector/border cells, grid cells and conjunctive cells, in the somatosensory cortex. These newly identified somatosensory spatial cells form a spatial map outside the hippocampal formation and support the hypothesis that location information modulates body representation in the somatosensory cortex. Our findings provide transformative insights into our understanding of how spatial information is processed and integrated in the brain, as well as functional operations of the somatosensory cortex in the context of rehabilitation with brain-machine interfaces.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.